{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:36:32Z","timestamp":1785771392786,"version":"3.56.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"unspecified","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Zygote"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>This study investigates the effects of psychopharmacological drug on male reproductive health, with a specific focus on sperm parameters, DNA integrity, and chromatin structure. The aim is to understand the potential risks these medications pose to fertility. A comparative analysis was conducted involving 14 individuals undergoing psychopharmacological treatment and 15 non-users. Key seminal parameters, including volume, concentration, count, morphology, and motility, were evaluated to assess the impact on overall sperm quality. Additionally, genetic markers such as DNA fragmentation and chromatin structural integrity were measured to determine the extent of damage to genetic material. The study also analysed Protein Kinase A (PKA) expression, a critical enzyme in the cAMP-mediated signalling pathway, to explore its role in regulating sperm function. Significant statistical differences were observed in semen parameters, DNA fragmentation, chromatin integrity, and PKA protein expression between the two groups. Individuals using psychopharmacological drugs exhibited marked impairments in sperm quality and genetic markers compared to non-users. These findings suggest a potential link between psychopharmacological drug use and adverse effects on male reproductive health. The study underscores the importance of understanding the reproductive risks associated with these medications. It highlights the need for increased awareness among healthcare professionals and patients about the potential consequences of psychopharmacological treatment on fertility. Further research is essential to explore the underlying mechanisms and develop strategies to mitigate these adverse effects, ensuring better reproductive outcomes for individuals undergoing such treatments.<\/jats:p>","DOI":"10.1017\/s0967199426100483","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:40:44Z","timestamp":1783928444000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the impact of psychopharmacological agents on spermatozoa parameters, genomic integrity and chromatin architecture"],"prefix":"10.1017","volume":"34","author":[{"given":"U\u011furcan","family":"Altiok","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Institute of Health Sciences, MSc Program, \u0130stanbul Medipol University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-5004","authenticated-orcid":false,"given":"Seda","family":"Karabulut","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/037jwzz50","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Histology and Embryology, International School of Medicine, \u0130stanbul Medipol University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2923-5869","authenticated-orcid":false,"given":"Oya","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"School of Medicine, Maltaya Turgut \u00d6zal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8987-3997","authenticated-orcid":false,"given":"Lima","family":"Oria","sequence":"additional","affiliation":[{"name":"International School of Medicine, \u0130stanbul Medipol University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"S0967199426100483_ref22","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2019.1614916"},{"key":"S0967199426100483_ref20","volume-title":"Global infertility prevalence estimates, 1990-2021","year":"2023"},{"key":"S0967199426100483_ref21","first-page":"84","article-title":"Selective serotonin reuptake inhibitors and semen quality: A systematic review and meta-analysis","volume":"108","author":"Xu","year":"2022","journal-title":"Reproductive Toxicology"},{"key":"S0967199426100483_ref10","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2016.10.03"},{"key":"S0967199426100483_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13072129"},{"key":"S0967199426100483_ref9","article-title":"Sperm epigenetics and intergenerational inheritance","volume":"31","author":"Donkin","year":"2020","journal-title":"Trends in Endocrinology and 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The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}