{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:16:20Z","timestamp":1763057780593,"version":"3.32.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":3986,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["intpsychogeriatrics.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Psychogeriatrics"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1017\/s1041610213001762","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T14:17:08Z","timestamp":1383056228000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial"],"prefix":"10.1016","volume":"26","author":[{"given":"Krista L.","family":"Lanct\u00f4t","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Chau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea T.","family":"Drye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul B.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta W.","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Bachman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobo E.","family":"Mintzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1017\/S1041610213001762_bb0010","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00002826-200601000-00005","article-title":"Effects of methylphenidate on cognitive function and gait in patients with Parkinson's disease: a pilot study","volume":"29","author":"Auriel","year":"2006","journal-title":"Clinical Neuropharmacology"},{"key":"10.1017\/S1041610213001762_bb0015","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/14640748608401616","article-title":"Dementia and working memory","volume":"38","author":"Baddeley","year":"1986","journal-title":"Quarterly Journal of Experimental Psychology"},{"key":"10.1017\/S1041610213001762_bb0020","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1016\/j.biopsych.2010.06.023","article-title":"Psychostimulants as cognitive enhancers: the prefrontal cortex, catecholamines, and attention-deficit\/hyperactivity disorder","volume":"69","author":"Berridge","year":"2011","journal-title":"Biological Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0025","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1136\/jnnp.2006.093146","article-title":"Attentional deficits affect activities of daily living in dementia-associated with Parkinson's disease","volume":"77","author":"Bronnick","year":"2006","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0030","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1016\/j.biopsych.2011.03.028","article-title":"Inverted-U-shaped dopamine actions on human working memory and cognitive control","volume":"69","author":"Cools","year":"2011","journal-title":"Biological Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0035","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1523\/JNEUROSCI.4467-08.2009","article-title":"Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration","volume":"29","author":"Cools","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"10.1017\/S1041610213001762_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(84)90341-0","article-title":"Striatal dopamine receptors in Alzheimer-type dementia","volume":"52","author":"Cross","year":"1984","journal-title":"Neuroscience Letters"},{"key":"10.1017\/S1041610213001762_bb0045","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","article-title":"Neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia","volume":"44","author":"Cummings","year":"1994","journal-title":"Neurology"},{"key":"10.1017\/S1041610213001762_bb0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clineuro.2007.08.007","article-title":"Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases: a SPECT study with partial volume effect correction","volume":"110","author":"David","year":"2008","journal-title":"Clinical Neurology and Neurosurgery"},{"key":"10.1017\/S1041610213001762_bb0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jagp.2012.12.018","article-title":"Designing a trial to evaluate potential treatments for apathy in dementia: the Apathy in Dementia Methylphenidate Trial (ADMET)","volume":"21","author":"Drye","year":"2013","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"Journal of Psychiatric Research"},{"key":"10.1017\/S1041610213001762_bb0065","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/WAD.0b013e3181630b81","article-title":"Effects of galantamine on measures of attention: results from 2 clinical trials in Alzheimer disease patients with comparisons to donepezil","volume":"22","author":"Galvin","year":"2008","journal-title":"Alzheimer Disease and Associated Disorders"},{"key":"10.1017\/S1041610213001762_bb0070","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1176\/jnp.9.2.231","article-title":"Methylphenidate treatment of negative symptoms in patients with dementia","volume":"9","author":"Galynker","year":"1997","journal-title":"Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"10.1017\/S1041610213001762_bb0075","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/JCP.0b013e318032eadb","article-title":"The influence of galantamine on reaction time, attention processes, and performance variability in elderly Alzheimer patients","volume":"27","author":"Gorus","year":"2007","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1017\/S1041610213001762_bb0080","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/alzrt176","article-title":"Separation of cognitive domains to improve prediction of progression from mild cognitive impairment to Alzheimer's disease","volume":"5","author":"Hendrix","year":"2013","journal-title":"Alzheimer's Research and Therapy"},{"key":"10.1017\/S1041610213001762_bb0085","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/JCP.0b013e318172b479","article-title":"Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge","volume":"28","author":"Herrmann","year":"2008","journal-title":"Journal of Clinical Psychopharmacology"},{"key":"10.1017\/S1041610213001762_bb0090","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/brb3.80","article-title":"Effects of motivation on reward and attentional networks: an fMRI study","volume":"2","author":"Ivanov","year":"2012","journal-title":"Brain Behavior"},{"key":"10.1017\/S1041610213001762_bb0095","first-page":"186","article-title":"Hedonic valence, dopamine and motivation","volume":"1","author":"Koob","year":"1996","journal-title":"Molecular Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0100","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1523\/JNEUROSCI.15-02-01308.1995","article-title":"Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methylphenidate","volume":"15","author":"Kuczenski","year":"1995","journal-title":"Journal of Neuroscience"},{"key":"10.1017\/S1041610213001762_bb0105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000103633","article-title":"A SPECT study of apathy in Alzheimer's disease","volume":"24","author":"Lanct\u00f4t","year":"2007","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"10.1017\/S1041610213001762_bb0110","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/JGP.0b013e318170a6d1","article-title":"Apathy associated with Alzheimer disease: use of dextroamphetamine challenge","volume":"16","author":"Lanct\u00f4t","year":"2008","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-1781(91)90040-V","article-title":"Reliability and validity of the Apathy Evaluation Scale","volume":"38","author":"Marin","year":"1991","journal-title":"Psychiatry Research"},{"key":"10.1017\/S1041610213001762_bb0120","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/jnnp.2008.164483","article-title":"Attention deficits in Alzheimer's disease and vascular dementia","volume":"81","author":"McGuinness","year":"2010","journal-title":"Journal of Neurology, Neurosurgery And Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1017\/S1355617702813182","article-title":"Apathy and executive function in Alzheimer's disease","volume":"8","author":"McPherson","year":"2002","journal-title":"Journal of the International Neuropsychological Society"},{"key":"10.1017\/S1041610213001762_bb0130","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1755-5949.2010.00161.x","article-title":"The role of dopamine in symptoms and treatment of apathy in Alzheimer's disease","volume":"17","author":"Mitchell","year":"2010","journal-title":"CNS Neuroscience and Therapeutics"},{"issue":"2","key":"10.1017\/S1041610213001762_bb0135","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00019052-200312002-00002","article-title":"Dopamine: a key regulator to adapt action, emotion, motivation and cognition","volume":"16","author":"Nieoullon","year":"2003","journal-title":"Current Opinion in Neurology"},{"key":"10.1017\/S1041610213001762_bb0140","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/JGP.0b013e3181cabcf6","article-title":"Methylphenidate for apathy and functional status in dementia of the Alzheimer type","volume":"18","author":"Padala","year":"2010","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0145","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s11682-012-9190-3","article-title":"Confirmatory factor analysis of the ADNI Neuropsychological Battery","volume":"6","author":"Park","year":"2012","journal-title":"Brain Imaging and Behavior"},{"issue":"3","key":"10.1017\/S1041610213001762_bb0150","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/brain\/122.3.383","article-title":"Attention and executive deficits in Alzheimer's disease. A critical review","volume":"122","author":"Perry","year":"1999","journal-title":"Brain"},{"key":"10.1017\/S1041610213001762_bb0155","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0028-3932(99)00079-2","article-title":"The nature and staging of attention dysfunction in early (minimal and mild) Alzheimer's disease: relationship to episodic and semantic memory impairment","volume":"38","author":"Perry","year":"2000","journal-title":"Neuropsychologia"},{"key":"10.1017\/S1041610213001762_bb0160","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00019442-200502000-00007","article-title":"Attention and executive control predict Alzheimer disease in late life: results from the Berlin Aging Study (BASE)","volume":"13","author":"Rapp","year":"2005","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0165","doi-asserted-by":"crossref","first-page":"810","DOI":"10.4088\/JCP.12m08099","article-title":"Safety and efficacy of methylphenidate for apathy in Alzheimer's disease: a randomized, placebo-controlled trial","volume":"74","author":"Rosenberg","year":"2013","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1017\/S1041610213001762_bb0170","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00002093-199700112-00004","article-title":"Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study","volume":"11","author":"Schneider","year":"1997","journal-title":"Alzheimer Disease and Associated Disorders"},{"key":"10.1017\/S1041610213001762_bb0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3940(95)12256-7","article-title":"Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients","volume":"203","author":"Storga","year":"1996","journal-title":"Neuroscience Letters"},{"key":"10.1017\/S1041610213001762_bb0180","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0009-9236(99)70038-X","article-title":"Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children","volume":"66","author":"Swanson","year":"1999","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1017\/S1041610213001762_bb0185","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s00702-005-0437-7","article-title":"Methylphenidate-induced improvements of various measures of attention in adults with attention deficit hyperactivity disorder","volume":"113","author":"Tucha","year":"2006","journal-title":"Journal of Neural Transmission"},{"key":"10.1017\/S1041610213001762_bb0190","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1185\/030079905X61884","article-title":"Early onset effects of galantamine treatment on attention in patients with Alzheimer's disease","volume":"21","author":"Vellas","year":"2005","journal-title":"Current Medical Research and Opinion"},{"year":"1981","series-title":"Wechsler Adult Intelligence Scale\u2013Revised, Manual","author":"Wheeler","key":"10.1017\/S1041610213001762_bb0195"}],"container-title":["International Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610224002023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610224002023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1041610213001762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:37:41Z","timestamp":1736401061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1041610224002023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S1041610224002023"],"URL":"https:\/\/doi.org\/10.1017\/s1041610213001762","relation":{},"ISSN":["1041-6102"],"issn-type":[{"type":"print","value":"1041-6102"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial","name":"articletitle","label":"Article Title"},{"value":"International Psychogeriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1017\/S1041610213001762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 International Psychogeriatric Association. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}