{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:08:03Z","timestamp":1771603683782,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":91,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["intpsychogeriatrics.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Psychogeriatrics"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1017\/s1041610220001143","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T08:07:59Z","timestamp":1594282079000},"page":"1021-1029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression"],"prefix":"10.1016","volume":"36","author":[{"given":"D.C.","family":"Steffens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.E.","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.L.","family":"Soldano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.R.","family":"McQuoid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.E.","family":"Ashley-Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.G.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1017\/S1041610220001143_bb0010","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1176\/ajp.150.11.1693","article-title":"The course of geriatric depression with \u201creversible dementia\u201d: a controlled study","volume":"150","author":"Alexopoulos","year":"1993","journal-title":"American Journal of Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0015","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"10.1017\/S1041610220001143_bb0020","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/archneur.1995.00540320035011","article-title":"Alzheimer\u2019s disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance","volume":"52","author":"Breitner","year":"1995","journal-title":"Archives of Neurology"},{"key":"10.1017\/S1041610220001143_bb0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/1567205017666200217104114","article-title":"Depression in dementia or dementia in depression? Systematic review of studies and hypotheses","volume":"17","author":"Brzezinska","year":"2020","journal-title":"Current Alzheimer Research"},{"key":"10.1017\/S1041610220001143_bb0030","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/archpsyc.61.6.587","article-title":"The nature and determinants of neuropsychological functioning in late-life depression","volume":"61","author":"Butters","year":"2004","journal-title":"Archives of General Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0035","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1212\/01.wnl.0000167607.63000.38","article-title":"A total score for the CERAD neuropsychological battery","volume":"65","author":"Chandler","year":"2005","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0040","first-page":"196","article-title":"Polymorphisms in the Cholinergic Receptors Muscarinic (CHRM2 and CHRM3) genes and Alzheimer\u2019s Disease","volume":"10","author":"Chee","year":"2018","journal-title":"Avicenna Journal of Medical Biotechnology"},{"key":"10.1017\/S1041610220001143_bb0045","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.1167\/iovs.10-5606","article-title":"Copy number variations and primary open-angle glaucoma","volume":"52","author":"Davis","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1017\/S1041610220001143_bb0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nmeth.1785","article-title":"A linear complexity phasing method for thousands of genomes","volume":"9","author":"Delaneau","year":"2011","journal-title":"Nature Methods"},{"key":"10.1017\/S1041610220001143_bb0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/archpsyc.1996.01830020093011","article-title":"Depressed mood and the incidence of Alzheimer\u2019s disease in the elderly living in the community","volume":"53","author":"Devanand","year":"1996","journal-title":"Archives of General Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0060","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1192\/bjp.bp.112.118307","article-title":"Late-life depression and risk of vascular dementia and Alzheimer\u2019s disease: systematic review and meta-analysis of community-based cohort studies","volume":"202","author":"Diniz","year":"2013","journal-title":"British Journal of Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0065","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/hmg\/ddt431","article-title":"Education influences the association between genetic variants and refractive error: a meta-analysis of five Singapore studies","volume":"23","author":"Fan","year":"2014","journal-title":"Human Molecular Genetics"},{"key":"10.1017\/S1041610220001143_bb0070","doi-asserted-by":"crossref","first-page":"e1094","DOI":"10.1038\/tp.2017.49","article-title":"Assessing the presence of shared genetic architecture between Alzheimer\u2019s disease and major depressive disorder using genome-wide association data","volume":"7","author":"Gibson","year":"2017","journal-title":"Translational Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0075","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2011.12.059","article-title":"Alzheimer\u2019s disease risk factor complement receptor 1 is associated with depression","volume":"10","author":"Hamilton","year":"2012","journal-title":"Neuroscience Letters"},{"key":"10.1017\/S1041610220001143_bb0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.yfrne.2015.12.001","article-title":"Depression as a risk factor for Alzheimer\u2019s disease: genes, steroids, cytokines and neurogenesis - what do we need to know?","volume":"41","author":"Herbert","year":"2016","journal-title":"Frontiers in Neuroendocrinology"},{"key":"10.1017\/S1041610220001143_bb0085","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLOS Genetics"},{"issue":"suppl 2","key":"10.1017\/S1041610220001143_bb0090","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1093\/ije\/20.Supplement_2.S43","article-title":"Psychiatric history and related exposures as risk factors for Alzheimer\u2019s disease: a collaborative re-analysis of case-control studies","volume":"20","author":"Jorm","year":"1991","journal-title":"International Journal of Epidemiology"},{"key":"10.1017\/S1041610220001143_bb0095","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1136\/jnnp-2014-308469","article-title":"Associations of cytokine genes with Alzheimer\u2019s disease and depression in an elderly Korean population","volume":"86","author":"Kang","year":"2015","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0100","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.12659\/MSM.907202","article-title":"Interactions among polymorphisms of susceptibility loci for Alzheimer\u2019s Disease or depressive disorder","volume":"24","author":"Kitzlerova","year":"2018","journal-title":"Medical Science Monitor"},{"key":"10.1017\/S1041610220001143_bb0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/JAD-148006","article-title":"Neuropsychological functioning in the acute and remitted states of late-life depression","volume":"45","author":"Koenig","year":"2015","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1017\/S1041610220001143_bb0110","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1212\/WNL.41.9.1393","article-title":"Clinical risk factors for Alzheimer\u2019s disease: a population-based case-control study","volume":"41","author":"Kokmen","year":"1991","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S1041610206003607","article-title":"Persistent mild cognitive impairment in geriatric depression","volume":"19","author":"Lee","year":"2007","journal-title":"International Psychogeriatrics"},{"key":"10.1017\/S1041610220001143_bb0120","first-page":"213","article-title":"Glioma and Alzheimer\u2019s Disease","volume":"2","author":"Lehrer","year":"2018","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1017\/S1041610220001143_bb0125","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41398-020-0769-y","article-title":"Shared genetic etiology underlying Alzheimer\u2019s Disease and major depressive disorder","volume":"10","author":"Lutz","year":"2020","journal-title":"Translational Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0130","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.jagp.2013.11.002","article-title":"Cognitive outcomes after psychotherapeutic interventions for major depression in older adults with executive dysfunction","volume":"22","author":"Mackin","year":"2014","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0135","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0140","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0145","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.39.9.1159","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer\u2019s disease","volume":"39","author":"Morris","year":"1989","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0150","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/jnc.14722","article-title":"Amyloid beta25-35 impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1\/SLC27A1) protein expression in human brain capillary endothelial cells","volume":"150","author":"Ochiai","year":"2019","journal-title":"Journal of Neurochemistry"},{"key":"10.1017\/S1041610220001143_bb0155","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1167\/iovs.12-10460","article-title":"Myopia and cognitive dysfunction: the Singapore Malay Eye Study","volume":"54","author":"Ong","year":"2013","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1017\/S1041610220001143_bb0160","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis","volume":"2","author":"Patterson","year":"2006","journal-title":"PLoS Genetics"},{"key":"10.1017\/S1041610220001143_bb0165","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.55.8.1158","article-title":"Documented head injury in early adulthood increases risk of Alzheimer\u2019s disease and other dementias 50 years later","volume":"55","author":"Plassman","year":"2000","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0170","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1375\/twin.9.6.950","article-title":"Duke twins study of memory in aging in the NAS-NRC Twin Registry","volume":"9","author":"Plassman","year":"2006","journal-title":"Twin Research and Human Genetics"},{"key":"10.1017\/S1041610220001143_bb0175","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000109998","article-title":"Prevalence of dementia in the United States: the aging, demographics, and memory study","volume":"29","author":"Plassman","year":"2007","journal-title":"Neuroepidemiology"},{"key":"10.1017\/S1041610220001143_bb0180","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"American Journal of Human Genetics"},{"key":"10.1017\/S1041610220001143_bb0185","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Ripke","year":"2014","journal-title":"Nature"},{"key":"10.1017\/S1041610220001143_bb0190","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.2.250","article-title":"Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop","volume":"43","author":"Roman","year":"1993","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0195","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/WAD.0b013e3181b76415","article-title":"The CERAD neuropsychologic battery total score and the progression of Alzheimer disease","volume":"24","author":"Rossetti","year":"2010","journal-title":"Alzheimer Disease and Associated Disorders"},{"key":"10.1017\/S1041610220001143_bb0200","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1176\/appi.ajp.2017.17040423","article-title":"Sensation and psychiatry: linking age-related hearing loss to late-life depression and cognitive decline","volume":"175","author":"Rutherford","year":"2018","journal-title":"American Journal of Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0205","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/STROKEAHA.118.020811","article-title":"Genetic study of white matter integrity in UK Biobank (N=8448) and the overlap with stroke, depression, and dementia","volume":"49","author":"Rutten-Jacobs","year":"2018","journal-title":"Stroke"},{"key":"10.1017\/S1041610220001143_bb0210","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1212\/WNL.0b013e3181e62138","article-title":"Depressive symptoms and risk of dementia: the Framingham Heart Study","volume":"75","author":"Saczynski","year":"2010","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0215","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer\u2019s disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"key":"10.1017\/S1041610220001143_bb0220","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ajhg.2009.12.017","article-title":"Homozygosity mapping reveals mutations of GRXCR1 as a cause of autosomal-recessive nonsyndromic hearing impairment","volume":"86","author":"Schraders","year":"2010","journal-title":"American Journal of Human Genetics"},{"key":"10.1017\/S1041610220001143_bb0225","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00001648-199507000-00006","article-title":"History of depression as a risk factor for Alzheimer\u2019s disease","volume":"6","author":"Speck","year":"1995","journal-title":"Epidemiology"},{"key":"10.1017\/S1041610220001143_bb0230","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ajhg.2017.03.009","article-title":"Dysfunction of the cerebral glucose transporter SLC45A1 in individuals with intellectual disability and epilepsy","volume":"100","author":"Srour","year":"2017","journal-title":"American Journal of Human Genetics"},{"key":"10.1017\/S1041610220001143_bb0235","first-page":"58","article-title":"The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach","volume":"36","author":"Steffens","year":"2002","journal-title":"Psychopharmacology Bulletin"},{"key":"10.1017\/S1041610220001143_bb0240","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/0891988708328213","article-title":"Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study","volume":"22","author":"Steffens","year":"2009","journal-title":"Journal of Geriatric Psychiatry and Neurology"},{"key":"10.1017\/S1041610220001143_bb0245","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0006-3223(96)00247-8","article-title":"A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer\u2019s disease","volume":"41","author":"Steffens","year":"1997","journal-title":"Biological Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0250","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/JGP.0b013e318048a1a0","article-title":"Longitudinal magnetic resonance imaging vascular changes, apolipoprotein E genotype, and development of dementia in the Neurocognitive Outcomes of Depression in the Elderly study","volume":"15","author":"Steffens","year":"2007","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0255","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1177\/0891988704269819","article-title":"Methodology and preliminary results from the Neurocognitive Outcomes of Depression in the Elderly study","volume":"17","author":"Steffens","year":"2004","journal-title":"Journal of Geriatric Psychiatry and Neurology"},{"key":"10.1017\/S1041610220001143_bb0260","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/jnnp.57.4.416","article-title":"Clinical and neuropathological criteria for frontotemporal dementia","volume":"57","author":"The Lund and Manchester Groups","year":"1994","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0265","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/ijc.22108","article-title":"Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction","volume":"119","author":"van den Boom","year":"2006","journal-title":"International Journal of Cancer"},{"key":"10.1017\/S1041610220001143_bb0270","doi-asserted-by":"crossref","first-page":"e1002287","DOI":"10.1371\/journal.pmed.1002287","article-title":"Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data","volume":"14","author":"White","year":"2017","journal-title":"PLOS Medicine"},{"key":"10.1017\/S1041610220001143_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-151129","article-title":"Shared genetic risk factors for late-life depression and Alzheimer\u2019s Disease","volume":"52","author":"Ye","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1017\/S1041610220001143_bb0280","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jagp.2016.06.009","article-title":"The ACE gene is Aasociated with late-life major depression and age at dementia onset in a population-based cohort","volume":"25","author":"Zettergren","year":"2017","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S1041610220001143_bb0285","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jpsychires.2009.12.002","article-title":"Neuropsychological profiles in MCI and in depression: differential cognitive dysfunction patterns or similar final common pathway disorder?","volume":"44","author":"Zihl","year":"2010","journal-title":"Journal of Psychiatric Research"}],"container-title":["International Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610225002492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610225002492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1041610220001143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T23:32:46Z","timestamp":1740526366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1041610225002492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1041610225002492"],"URL":"https:\/\/doi.org\/10.1017\/s1041610220001143","relation":{},"ISSN":["1041-6102"],"issn-type":[{"value":"1041-6102","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression","name":"articletitle","label":"Article Title"},{"value":"International Psychogeriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1017\/S1041610220001143","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 International Psychogeriatric Association 2020. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}