{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T10:59:06Z","timestamp":1791716346878,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":425,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["intpsychogeriatrics.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Psychogeriatrics"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1017\/s104161022200117x","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T04:48:56Z","timestamp":1675054136000},"page":"623-632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Neuropsychiatric symptoms and their neural correlates in individuals with mild cognitive impairment"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-0494","authenticated-orcid":false,"given":"Natascia","family":"De Lucia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Muzii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Mauro","family":"Maldonato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-483X","authenticated-orcid":false,"given":"Grazia Daniela","family":"Femminella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1017\/S104161022200117X_bb0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1567205013666160603010203","article-title":"Neuroimaging findings related to behavioral disturbances in Alzheimer\u2019s disease: a systematic review","volume":"14","author":"Alves","year":"2017","journal-title":"Current Alzheimer Research"},{"key":"10.1017\/S104161022200117X_bb0015","series-title":"Diagnostic and statistical manual of mental disorders (DSM-IV)","author":"American Psychiatric Association (APA)","year":"1994"},{"key":"10.1017\/S104161022200117X_bb0020","first-page":"231469","article-title":"Apathy and emotion-based decision making in amnesic mild cognitive impairment and Alzheimer\u2019s disease","volume":"2014","author":"Bayard","year":"2014","journal-title":"Behavioral Neurology"},{"key":"10.1017\/S104161022200117X_bb0025","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/JGP.0b013e31817945c3","article-title":"Late-life anxiety and cognitive impairment: a review","volume":"16","author":"Beaudreau","year":"2008","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0030","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000363500","article-title":"Agitation in dementia: relation to core cerebrospinal fluid biomarker levels","volume":"4","author":"Bloniecki","year":"2014","journal-title":"Dementia and Geriatric Cognitive Disorders Extra"},{"key":"10.1017\/S104161022200117X_bb0035","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/ene.13076","article-title":"Neuroimaging correlates of neuropsychiatric symptoms in Alzheimer\u2019s disease: a review of 20 years of research","volume":"23","author":"Boublay","year":"2016","journal-title":"European Journal of Neurology"},{"key":"10.1017\/S104161022200117X_bb0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-2012-120169","article-title":"Neuropsychiatric symptoms in older people with and without cognitive impairment","volume":"31","author":"Brodaty","year":"2012","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1017\/S104161022200117X_bb0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/arclin\/11.6.529","article-title":"Screening for dementia of the Alzheimer type in the community: the utility of the Clock Drawing Test","volume":"11","author":"Cahn","year":"1996","journal-title":"Archives of Clinical Neuropsychology"},{"key":"10.1017\/S104161022200117X_bb0050","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41386-022-01293-6","article-title":"Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer\u2019s disease","volume":"47","author":"Cassidy","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1017\/S104161022200117X_bb0055","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1212\/WNL.48.5_Suppl_6.10S","article-title":"The Neuropsychiatric Inventory: assessing psychopathology in dementia patients","volume":"48","author":"Cummings","year":"1997","journal-title":"Neurology"},{"key":"10.1017\/S104161022200117X_bb0060","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/gps.4161","article-title":"Apathy as a feature of prodromal Alzheimer\u2019s disease: an FDG-PET ADNI study","volume":"30","author":"Delrieu","year":"2015","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0065","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1080\/13803395.2015.1071339","article-title":"Closing-in in Parkinson\u2019s disease individuals with dementia: an experimental study","volume":"37","author":"De Lucia","year":"2015","journal-title":"Journal of Clinical and Experimental Neuropsychology"},{"key":"10.1017\/S104161022200117X_bb0070","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.parkreldis.2017.12.008","article-title":"Cognitive profile and 18F-fluorodeoxyglucose PET study in LRRK2-related Parkinson\u2019s disease","volume":"47","author":"De Rosa","year":"2018","journal-title":"Parkinsonism and Related Disorders"},{"key":"10.1017\/S104161022200117X_bb0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-200578","article-title":"The differential influence of immune, endocytotic, and lipid metabolism genes on amyloid deposition and neurodegeneration in subjects at risk of Alzheimer\u2019s disease","volume":"79","author":"Femminella","year":"2021","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1017\/S104161022200117X_bb0080","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-mental state","volume":"12","author":"Folstein","year":"1975","journal-title":"Journal of Psychiatric Research"},{"key":"10.1017\/S104161022200117X_bb0085","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1093\/geronb\/gbz032","article-title":"Hallucinations and delusions signal Alzheimer\u2019s associated cognitive dysfunction more strongly compared to other neuropsychiatric symptoms","volume":"75","author":"Fuller","year":"2020","journal-title":"Journal of Gerontology. Serie B, Psychological Sciences and Social Sciences"},{"key":"10.1017\/S104161022200117X_bb0090","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/psyg.12363","article-title":"Medial temporal lobe atrophy is independently associated with behavioural and psychological symptoms in Alzheimer\u2019s disease","volume":"19","author":"Garc\u00eda-Alberca","year":"2008","journal-title":"Psychogeriatrics"},{"key":"10.1017\/S104161022200117X_bb0095","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/archpsyc.65.10.1193","article-title":"Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study","volume":"65","author":"Geda","year":"2008","journal-title":"Archives of General Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0100","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1176\/appi.ajp.2014.13060821","article-title":"Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study","volume":"171","author":"Geda","year":"2014","journal-title":"American Journal of Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0105","first-page":"594","article-title":"AffiliatioSelf-ratings of spoken language dominance: a multi-lingual naming test (MlNT) and preliminary norms for young and aging Spanish-English bilinguals","volume":"15","author":"Gollan","year":"2012","journal-title":"Bilingualism (Cambridge, England)"},{"key":"10.1017\/S104161022200117X_bb0110","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3233\/JAD-141257","article-title":"Closing-in is related to apathy in Alzheimer\u2019s disease patients","volume":"43","author":"Grossi","year":"2015","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1017\/S104161022200117X_bb0115","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3233\/JAD-200190","article-title":"Affective neuropsychiatric symptoms as early signs of dementia risk in older adults","volume":"77","author":"Jang","year":"2020","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1017\/S104161022200117X_bb0120","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3233\/JAD-215417","article-title":"The role of amyloid, tau, and APOE genotype on the relationship between informant-reported sleep disturbance and Alzheimer\u2019s disease risks","volume":"87","author":"Kim","year":"2022","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"10.1017\/S104161022200117X_bb0125","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/jama.288.12.1475","article-title":"Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment","volume":"288","author":"Lyketsos","year":"2002","journal-title":"Journal of the American Medical Association"},{"key":"10.1017\/S104161022200117X_bb0130","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/alz.12007","article-title":"Mild behavioral impairment is associated with \u03b2-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals","volume":"16","author":"Lussier","year":"2020","journal-title":"Alzheimers Dementia"},{"key":"10.1017\/S104161022200117X_bb0135","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jagp.2014.10.005","article-title":"Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease","volume":"23","author":"Mah","year":"2015","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3233\/JAD-180131","article-title":"Assessing mild behavioral impairment with the mild behavioral impairment checklist in people with mild cognitive impairment","volume":"66","author":"Mallo","year":"2018","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1017\/S104161022200117X_bb0145","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.2147\/CIA.S264688","article-title":"Activities of daily living and associated costs in the most widespread neurodegenerative diseases: a systematic review","volume":"15","author":"Maresova","year":"2020","journal-title":"Clinical Interventions in Aging"},{"key":"10.1017\/S104161022200117X_bb0150","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000507078","article-title":"Neuropsychiatric symptoms in mild cognitive impairment: a literature review","volume":"49","author":"Martin","year":"2020","journal-title":"Dementia and Geriatric Cognition Disorders"},{"key":"10.1017\/S104161022200117X_bb0155","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1017\/S104161022200117X_bb0160","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1212\/WNL.0000000000003916","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease","volume":"9","author":"Ng","year":"2017","journal-title":"Neurology"},{"key":"10.1017\/S104161022200117X_bb0165","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/JAD-2010-1352","article-title":"Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer\u2019s disease: the role of depression and apathy","volume":"20","author":"Palmer","year":"2010","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1017\/S104161022200117X_bb0170","doi-asserted-by":"crossref","first-page":"e056204","DOI":"10.1002\/alz.056204","article-title":"Longitudinal associations of regional cortical tau and apathy in mild cognitive impairment and Alzheimer\u2019s disease dementia: findings from the Alzheimer\u2019s Disease Neuroimaging Initiative","volume":"17","author":"Premnath","year":"2021","journal-title":"Alzheimer\u2019s Dementia"},{"key":"10.1017\/S104161022200117X_bb0175","doi-asserted-by":"crossref","first-page":"595758","DOI":"10.3389\/fnagi.2021.595758","article-title":"Correlation of frontal atrophy and CSF tau levels with neuropsychiatric symptoms in patients with cognitive impairment: a memory clinic experience","volume":"13","author":"Ramusino","year":"2021","journal-title":"Frontiers in Aging Neuroscience"},{"key":"10.1017\/S104161022200117X_bb0180","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1017\/S0033291712001870","article-title":"Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment","volume":"43","author":"Ramakers","year":"2013","journal-title":"Psychological Medicine"},{"key":"10.1017\/S104161022200117X_bb0185","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","article-title":"Validity of the trail-making test as an indicator of organic brain damage","volume":"8","author":"Reitan","year":"1958","journal-title":"Perception and Motor Skills"},{"key":"10.1017\/S104161022200117X_bb0190","series-title":"L\u2019examen Clinique en psychologie","author":"Rey","year":"1964"},{"key":"10.1017\/S104161022200117X_bb0195","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer\u2019s disease","volume":"141","author":"Rosen","year":"1984","journal-title":"American Journal of Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0200","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3233\/JAD-190365","article-title":"Cerebrospinal fluid correlates of neuropsychiatric symptoms in patients with Alzheimer\u2019s Disease\/Mild Cognitive Impairment: a systematic review","volume":"71","author":"Showraki","year":"2019","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1017\/S104161022200117X_bb0205","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1017\/S1041610221000934","article-title":"Neuropsychiatric symptoms and brain morphology in patients with mild cognitive impairment and Alzheimer\u2019s disease with dementia","volume":"33","author":"Siafarikas","year":"2021","journal-title":"International Psychogeriatrics"},{"key":"10.1017\/S104161022200117X_bb0210","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41398-021-01675-2","article-title":"Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology","volume":"11","author":"Sun","year":"2021","journal-title":"Translational Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0215","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1176\/appi.ajp.20220508","article-title":"Dementia is more than memory loss: neuropsychiatric symptoms of dementia and their non-pharmacological and pharmacological management","volume":"179","author":"Tampi","year":"2022","journal-title":"American Journal of Psychiatry"},{"key":"10.1017\/S104161022200117X_bb0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1176\/appi.neuropsych.16080155","article-title":"Noncognitive behavioral changes associated with Alzheimer\u2019s disease: implications of neuroimaging findings","volume":"30","author":"Victoroff","year":"2018","journal-title":"Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"10.1017\/S104161022200117X_bb0225","series-title":"Manual for the Wechsler Memory Scale-revised","author":"Wechsler","year":"1987"},{"key":"10.1017\/S104161022200117X_bb0230","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/psyg.12379","article-title":"Decreased perfusion of the posterior cingulate gyri shown by a cingulate island score is a possible marker of vulnerability to behavioural and psychological symptoms of Alzheimer\u2019s disease: a pilot study","volume":"19","author":"Yasuno","year":"2019","journal-title":"Psychogeriatrics"}],"updated-by":[{"DOI":"10.1017\/s1041610223000376","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000}}],"container-title":["International Psychogeriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610224030151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1041610224030151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104161022200117X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T01:01:52Z","timestamp":1735779712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1041610224030151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1041610224030151"],"URL":"https:\/\/doi.org\/10.1017\/s104161022200117x","relation":{},"ISSN":["1041-6102"],"issn-type":[{"value":"1041-6102","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuropsychiatric symptoms and their neural correlates in individuals with mild cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"International Psychogeriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1017\/S104161022200117X","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2023 International Psychogeriatric Association 2023. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}