{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T21:54:41Z","timestamp":1723240481576},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T00:00:00Z","timestamp":1155600000000},"content-version":"unspecified","delay-in-days":1687,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p><jats:italic>Aims:<\/jats:italic> Measurement of electrocardiographic intervals to assess dispersion in ventricular repolarization may be helpful in the assessment of the risk of ventricular arrhythmia. We measured QTc, QT dispersion, and T wave intervals in premature infants before and while on treatment with the I<jats:sub>Kr<\/jats:sub> blocker cisapride as markers for dispersion in ventricular repolarization. <jats:italic>Methods and Results:<\/jats:italic> We enrolled 15 non-ventilated premature infants with a mean gestational age of 30.5 weeks, ranging from 26.5 to 33.5 weeks, and mean postnatal age of 24 days, with a range from 5 to 51 days. A digital 12 lead electrocardiogram was recorded prior to and 3 days after administering cisapride at a dose of 0.8mg\/kg\/day. Serum electrolytes were simultaneously measured. Electrocardiographic measurements before and after included: QT, QTc Bazett, QT dispersion, R\u2013R, T wave interval peak to end, T wave interval peak to end\/onset Q to T wave peak, T wave axis, T wave maximum voltage and QRS\u2013T angle. A paired <jats:italic>t<\/jats:italic> test and analysis of variance was used to compare the variables before and during treatment. The QTc, T wave interval peak to end and the ratio T wave interval peak to end\/onset Q to T peak increased significantly following treatment with cisapride. Results expressed as before and during treatment were for QTc: 429 (65) ms versus 454 (29) ms p &lt; 0.02; for T wave interval peak to end: 65 (11) ms versus 103 (24) p &lt; 0.01, for the ratio T wave interval peak to end\/onset Q to T peak: 0.32 (0.06) versus 0.55 (0.16) p &lt; 0.001. Treatment with the I<jats:sub>Kr<\/jats:sub> blocker did not significantly alter the QT dispersion, T wave voltage, angle or QRS\u2013T angle. <jats:italic>Conclusion:<\/jats:italic> The interval from the peak to the end of the T wave and the ratio of this value to the onset Q to T peak interval, represents regional dispersion of repolarization across the ventricular wall. This is a potentially useful clinical index in the assessment of arrhythmic risk in premature infants being treated by blockade of the I<jats:sub>Kr<\/jats:sub> channels.<\/jats:p>","DOI":"10.1017\/s1047951102000069","type":"journal-article","created":{"date-parts":[[2006,8,15]],"date-time":"2006-08-15T12:09:01Z","timestamp":1155643741000},"page":"32-36","source":"Crossref","is-referenced-by-count":9,"title":["The T wave as a marker of dispersion of ventricular repolarization in premature infants before and while on treatment with the I<sub>Kr<\/sub> channel blocker cisapride"],"prefix":"10.1017","volume":"12","author":[{"given":"Avram","family":"Benatar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Cools","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine","family":"Decraene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Bougatef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvan","family":"Vandenplas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,8,15]]},"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951102000069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T20:20:01Z","timestamp":1557260401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951102000069\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S1047951102000069"],"URL":"https:\/\/doi.org\/10.1017\/s1047951102000069","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}