{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:32:09Z","timestamp":1787697129515,"version":"build-2784847793"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T00:00:00Z","timestamp":1116892800000},"content-version":"unspecified","delay-in-days":662,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:p>Aerosolized iloprost is now used as a therapeutic option in the treatment of pulmonary hypertension. We report on the administration of this derivative of prostacycline in treating severe pulmonary hypertension of the newborn. The combination of iloprost instilled endotracheally and inhaled was chosen as a last attempt at treatment in a critically ill patient who did not respond to advanced conventional treatments, including high frequency oscillation and inhalation of nitric oxide. The use of iloprost converted permanently the right-to-left shunting, leading to a substantial improvement in oxygenation.<\/jats:p>","DOI":"10.1017\/s1047951103000726","type":"journal-article","created":{"date-parts":[[2013,10,7]],"date-time":"2013-10-07T04:45:53Z","timestamp":1381121153000},"page":"361-363","source":"Crossref","is-referenced-by-count":42,"title":["Iloprost in persistent pulmonary hypertension of the newborn"],"prefix":"10.1017","volume":"13","author":[{"given":"Michael","family":"Ehlen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Wiebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2005,5,24]]},"reference":[{"key":"S1047951103000726_ref004","doi-asserted-by":"crossref","unstructured":"Olschewski H , Simonneau G , Galie N , et al. Inhaled Iloprost for severe pulmonary hypertension. N Engl J Med 2002; 347: 322\u2013329.","DOI":"10.1056\/NEJMoa020204"},{"key":"S1047951103000726_ref009","unstructured":"Olschewski H , Grimminger F , Seeger W . Therapie der pulmonalen Hypertonie. In: Sch\u00e4fers HJ , Seeger W (eds). Pulmonale Hypertonie, Blackwell Wiss.-Verl, 2000, pp 83\u2013106."},{"key":"S1047951103000726_ref003","unstructured":"K\u00f6ster S , Ahrens P , Kohl M , Wygold T . Verhindert fr\u00fchzeitig inhalativ verabreichtes Iloprost beim Krankheitsbild der persistierenden pulmonalen Hypertonie (PPHN) die Intubationsh\u00e4ufigkeit? Anwendungsbeobachtung bei 6 Patienten. Kinder\u00e4rztliche Praxis 2002; 6: 18, V48."},{"key":"S1047951103000726_ref007","doi-asserted-by":"crossref","unstructured":"Max M , Rossaint R . Inhaled prostacyclin in the treatment of pulmonary hypertension. Eur J Pediatr 1999; 158 (Suppl I): I23\u2013I26.","DOI":"10.1007\/PL00014316"},{"key":"S1047951103000726_ref005","unstructured":"R\u00f6mer U , Kozlik-Feldmann R , Behr J . Inhalatives Iloprost zur Therapie der schweren pulmonalen Hypertension: Erste Erfahrungen im Kindesalter. Zeitschrift f\u00fcr Kardiologie 2001; 90: 680."},{"key":"S1047951103000726_ref001","doi-asserted-by":"crossref","unstructured":"Ehlen M , Esser R , Kipping T . Inhalative Anwendung von Iloprost bei pulmonaler Hypertonie und respiratorischer Insuffizienz im Kindesalter. Monatsschr Kinderheilkd 2003; 151: 539\u2013543.","DOI":"10.1007\/s00112-002-0497-9"},{"key":"S1047951103000726_ref008","doi-asserted-by":"crossref","unstructured":"Eronen M , Pohjavuori M , Andersson S , Pesonen E , Raivio KO . Prostacyclin treatment for persistent pulmonary hypertension of newborn. Pediatr Cardiol 1997; 18: 3\u20137.","DOI":"10.1007\/s002469900099"},{"key":"S1047951103000726_ref006","doi-asserted-by":"crossref","unstructured":"Lambert V , Serraf A , Durand P , Losay J . Aerosolized iloprost therapy in an infant with chronic pulmonary hypertension after a neonatal arterial switch operation. Arch Pediatr 2001; 8: 1218\u20131221.","DOI":"10.1016\/S0929-693X(01)00638-8"},{"key":"S1047951103000726_ref002","unstructured":"M\u00f6ller JC . Iloprost inhalation in early therapy of pediatric lung failure. Journal f\u00fcr An\u00e4sthesie und Intensivbehandlung 2000; 7: 150."},{"key":"S1047951103000726_ref010","doi-asserted-by":"crossref","unstructured":"De Jaegere AP , van den Anker JN . Endotracheal instillation of prostacyclin in preterm infants with persistent pulmonary hypertension. Eur Resp J 1998; 12: 932\u2013934.","DOI":"10.1183\/09031936.98.12040932"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951103000726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T15:42:56Z","timestamp":1554997376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951103000726\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S1047951103000726"],"URL":"https:\/\/doi.org\/10.1017\/s1047951103000726","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}