{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:45:01Z","timestamp":1744173901359},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T00:00:00Z","timestamp":1114128000000},"content-version":"unspecified","delay-in-days":52,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>We describe an infant with an atrioventricular septal defect and separate valvar orifices for the right and left ventricles, the so-called primum defect, who presented with serious pulmonary hypertension. Treatment with sildenafil was changed to intravenous epoprostenol due to lack of any measurable effects of the initial therapy as shown by echocardiography. The girl died three days after the change in treatment. We suggest that a mismatch between ventilation and perfusion contributed significantly to her death.<\/jats:p>","DOI":"10.1017\/s1047951105000442","type":"journal-article","created":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T09:54:47Z","timestamp":1114163687000},"page":"223-225","source":"Crossref","is-referenced-by-count":5,"title":["Sudden death during a change in treatment for pulmonary hypertension"],"prefix":"10.1017","volume":"15","author":[{"given":"Henrik","family":"Brun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Thaulow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,4,22]]},"reference":[{"key":"S1047951105000442_ref002","doi-asserted-by":"crossref","unstructured":"Barst RJ , Maislin G , Fishman AP . Vasodilator therapy for primary pulmonary hypertension in children. Circulation 1999; 99: 1197\u20131208.","DOI":"10.1161\/01.CIR.99.9.1197"},{"key":"S1047951105000442_ref008","doi-asserted-by":"crossref","unstructured":"Haworth SG . Pulmonary vascular disease in secundum atrial septal defect in childhood. Am J Cardiol 1983; 51: 265\u2013272.","DOI":"10.1016\/S0002-9149(83)80047-2"},{"key":"S1047951105000442_ref004","doi-asserted-by":"crossref","unstructured":"Castro PF , Bourge RC , McGiffin DC , et al. Intrapulmonary shunting in primary pulmonary hypertension: an observation in two patients treated with epoprostenol sodium. Chest 1998; 114: 334\u2013336.","DOI":"10.1378\/chest.114.1.334"},{"key":"S1047951105000442_ref003","doi-asserted-by":"crossref","unstructured":"Yamaki S , Abe A , Sato K , Takahashi T . Microatelectasis in patients with secundum atrial septal defect and its relation to pulmonary hypertension. Jpn Circ J 1997; 61: 384\u2013389.","DOI":"10.1253\/jcj.61.384"},{"key":"S1047951105000442_ref001","doi-asserted-by":"crossref","unstructured":"Rosenzweig EB , Kerstein D , Barst RJ . Long-term prostacyclin for pulmonary hypertension with associated congenital heart defects. Circulation 1999; 99: 1858\u20131865.","DOI":"10.1161\/01.CIR.99.14.1858"},{"key":"S1047951105000442_ref007","doi-asserted-by":"crossref","unstructured":"Andrews R , Tulloh R , Magee A , Anderson D . Atrial septal defect with failure to thrive in infancy: hidden pulmonary vascular disease? Pediatr Cardiol 2002; 23: 528\u2013530.","DOI":"10.1007\/PL00021008"},{"key":"S1047951105000442_ref006","doi-asserted-by":"crossref","unstructured":"Falk A , Lookstein RA , Mitty HA . Flolan infusion interruption: a lethal complication during venous access. J Vasc Interv Radiol 2001; 12: 667\u2013668.","DOI":"10.1016\/S1051-0443(07)61499-7"},{"key":"S1047951105000442_ref005","doi-asserted-by":"crossref","unstructured":"Bush A , Busst CM , Knight WB , Shinebourne EA . Effects of infusion of prostacyclin on anatomical intrapulmonary right to left shunt: a useful model of human hypoxic vasoconstriction? Clin Sci 1989; 76: 143\u2013149.","DOI":"10.1042\/cs0760143"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951105000442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T18:56:57Z","timestamp":1554663417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951105000442\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S1047951105000442"],"URL":"https:\/\/doi.org\/10.1017\/s1047951105000442","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}