{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:43:51Z","timestamp":1762505031543},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T00:00:00Z","timestamp":1115078400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p>A recent, randomised, double-blind, placebo-controlled trial has demonstrated the effectiveness of palivizumab (Synagis<jats:sup>\u00ae<\/jats:sup>) for prophylaxis against infection by the respiratory syncytial virus in 1,287 young children with congenital cardiac disease. Guidelines for the use of palivizumab in these children considered to be at high risk were published by the American Academy of Pediatrics, followed by similar guidelines from the British Paediatric Cardiac Association, and recommendations from a number of other individual countries, including Canada, Germany, Spain, and France.<\/jats:p><jats:p>In May, 2004, further discussion was held between a group of 15 paediatric cardiologists at a European forum for clinical management held in Munich, Germany. The objective of this forum was to define optimal recommendations on prevention of infection by the respiratory syncytial virus in infants and young children with congenital cardiac disease, appropriate to the clinical needs and style of those practising in paediatrics in individual countries. Participants were invited because of their knowledge of the therapeutic area, and for their experience of using palivizumab for prophylaxis against the respiratory syncytial virus in children with congenitally malformed hearts. Measures to educate the carers of children with such congenital malformations on precautions against infection by the respiratory syncytial virus were discussed, along with the many different aspects of best practice for therapeutic prophylaxis with palivizumab. The most appropriate timing of prophylaxis, recommendations for which children are most likely to benefit from prophylaxis, and suggested protocols were among the issues covered. The recommendations resulting from the discussions are presented in this paper, as a step towards reaching consensus.<\/jats:p>","DOI":"10.1017\/s1047951105000569","type":"journal-article","created":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T11:10:35Z","timestamp":1115118635000},"page":"274-278","source":"Crossref","is-referenced-by-count":17,"title":["The European Forum for Clinical Management: prophylaxis against the respiratory syncytial virus in infants and young children with congenital cardiac disease"],"prefix":"10.1017","volume":"15","author":[{"given":"Robert M. R.","family":"Tulloh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy F.","family":"Feltes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,5,3]]},"reference":[{"key":"S1047951105000569_ref011","doi-asserted-by":"crossref","unstructured":"Feltes TF , Cabalka AK , Meissner HC , et al. Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr 2003; 143: 532\u2013540.","DOI":"10.1067\/S0022-3476(03)00454-2"},{"key":"S1047951105000569_ref017","unstructured":"Su\u00e1rez Cabrera P , Malo Concepci\u00f3n P , Maroto E , Santos de Soto J . Recomendaciones de la Sociedad Espa\u00f1ola de Cardiolog\u00eda Pedi\u00e1trica y Cardiopat\u00edas Cong\u00e9nitas para la prevenci\u00f3n de la infecci\u00f3n por virus respiratorio sincitial en pacientes con cardiopat\u00eda cong\u00e9nita. 2004. http:\/\/www.secardioped.org\/"},{"key":"S1047951105000569_ref005","doi-asserted-by":"crossref","unstructured":"Greenough A , Cox S , Alexander J , et al. Health care utilisation of infants with chronic lung disease, related to hospitalisation for RSV infection. Arch Dis Child 2001; 85: 463\u2013468.","DOI":"10.1136\/adc.85.6.463"},{"key":"S1047951105000569_ref004","doi-asserted-by":"crossref","unstructured":"Leader S , Kohlhase K . Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999. Pediatr Infect Dis J 2002; 21: 629\u2013632.","DOI":"10.1097\/00006454-200207000-00005"},{"key":"S1047951105000569_ref023","unstructured":"Feltes TF , Simoes EAF . Letter to Editor. Arch Dis Child. http:\/\/adc.bmjjournals.com, posted 20\/12\/04."},{"key":"S1047951105000569_ref014","unstructured":"Joint Committee on Vaccination and Immunisation. Minutes of the meeting held on Friday 1 November 2002 at 10.30. http:\/\/www.advisorybodies.doh.gov.uk\/jcvi\/mins01nov02.htm"},{"key":"S1047951105000569_ref016","unstructured":"Schmaltz AA . Stellungnahme der Deutschen Gesellschaft f\u00fcr P\u00e4diatrische Kardiologie zur RSV-Prophylaxe mit Palivizumab (Synagis\u00ae). Monatsschr Kinderheilkd 2004; 152: 222\u2013223."},{"key":"S1047951105000569_ref026","doi-asserted-by":"crossref","unstructured":"Rackham OJ , Thorburn K , Kerr SJ . The potential impact of prophylaxis against bronchiolitis due to the respiratory syncytial virus in children with congenital cardiac malformations. Cardiol Young 2005; 15: 251\u2013255.","DOI":"10.1017\/S1047951105000533"},{"key":"S1047951105000569_ref025","unstructured":"Keeton B . Re: Recommendation for the use of palivizumab as prophylaxis against respiratory syncytial virus in infants with congenital cardiac disease. Cardiol Young 2004; 14: 469."},{"key":"S1047951105000569_ref010","doi-asserted-by":"crossref","unstructured":"Simoes EA . Immunoprophylaxis of respiratory syncytial virus: global experience. Respir Res 2002; 3 (Suppl 1): S26\u2013S33.","DOI":"10.1186\/rr187"},{"key":"S1047951105000569_ref008","doi-asserted-by":"crossref","unstructured":"Gilchrist S , Torok TJ , Gary HE Jr , Alexander JP , Anderson LJ . National surveillance for respiratory syncytial virus, United States, 1985\u20131990. J Infect Dis 1994; 170: 986\u2013990.","DOI":"10.1093\/infdis\/170.4.986"},{"key":"S1047951105000569_ref001","doi-asserted-by":"crossref","unstructured":"Glezen WP , Taber LH , Frank AL , Kasel JA . Risk of primary infection and reinfection with respiratory syncytial virus. 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