{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:55:16Z","timestamp":1761807316836,"version":"3.41.0"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T00:00:00Z","timestamp":1169510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Patients with anomalous origin of the left coronary artery from the pulmonary trunk may present with paroxysmal angina on exertion, congestive heart failure, dyspnoea, syncope or sudden death. The association of such anomalous origin of the left coronary artery from the pulmonary trunk with a hypertrophic left ventricle is extremely rare. In our cohort of patients with anomalous origin of the left coronary artery from the pulmonary trunk, two presented with a hypertrophic left ventricle. We discuss these cases, accompanied by a review of the English literature describing different morphological anomalies of the coronary arteries associated with left ventricular hypertrophy. Whether the hypertrophy is a result of the evolvement of the collateral coronary system, or due to an additional pathological gene for hypertrophic obstructive cardiomyopathy, remains an enigma. The hypertrophy may have served as a compensatory mechanism accounting for the atypical clinical presentation. We further discuss the possible factors associating the occurrence of anomalous origin of the left coronary artery from the pulmonary trunk and myohypertrophy, supported by the documentation of the regression of hypertrophy following surgical correction of the anomalous arterial origin as seen in our patients.<\/jats:p>","DOI":"10.1017\/s104795110700008x","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T14:47:31Z","timestamp":1169563651000},"page":"78-83","source":"Crossref","is-referenced-by-count":2,"title":["Anomalous origin of the main stem of the left coronary artery from the pulmonary trunk presenting with left ventricular hypertrophy"],"prefix":"10.1017","volume":"17","author":[{"given":"Liat","family":"Gelernter-Yaniv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avraham","family":"Lorber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,1,23]]},"reference":[{"key":"S104795110700008X_ref006","doi-asserted-by":"crossref","unstructured":"Tai Y , Fong P , Chow W . Bilateral coronary artery to pulmonary artery fistula coexistence with apical hypertrophic cardiomyopathy \u2013 a case report. Angiology 1992; 43: 72\u201375.","DOI":"10.1177\/000331979204300109"},{"key":"S104795110700008X_ref010","doi-asserted-by":"crossref","unstructured":"Beach L , Burke A , Chute D , Virmani R . Anomalous origin of four coronary ostia from the right sinus of valsalva in a patient with hypertrophic cardiomyopathy. Arch Pathol Lab Med 2001; 125: 1489\u20131490.","DOI":"10.5858\/2001-125-1489-AOOCOF"},{"key":"S104795110700008X_ref002","unstructured":"Paquet M , Hanna B . Cardiomyopathies. In: Garson A , Bricker J , McNamara D (eds). The science and practice of Pediatric Cardiology. Vol. III Lea & Febiger, Philadelphia\/London, 1990, pp1926\u20131934."},{"key":"S104795110700008X_ref004","doi-asserted-by":"crossref","unstructured":"Yamazaki T , Komuro I , Kudoh S , et al. Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. 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Septal ablation in a patient with hypertrophic obstructive cardiomyopathy and a unique variant of anomalous origin of the left coronary artery. Heart 1998; 79: 629\u2013630.","DOI":"10.1136\/hrt.79.6.629"},{"key":"S104795110700008X_ref003","doi-asserted-by":"crossref","unstructured":"Komuro I . Molecular mechanism of cardiac hypertrophy and development. Jpn Circ J 2001; 65: 353\u2013358.","DOI":"10.1253\/jcj.65.353"},{"key":"S104795110700008X_ref001","unstructured":"Matherne G . Moss and Adams' Congenital anomalies of coronary arteries. In: Allen H , et al. (eds). Heart disease in infants, children, and adolescents. Lippincott Williams & Wilkins, 2001, pp675\u2013688."}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795110700008X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:54:52Z","timestamp":1750492492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795110700008X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,23]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S104795110700008X"],"URL":"https:\/\/doi.org\/10.1017\/s104795110700008x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2007,1,23]]}}}