{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T09:44:22Z","timestamp":1772012662484,"version":"3.50.1"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T00:00:00Z","timestamp":1193184000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S104795110700145X_abs1\" sec-type=\"general\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>To determine the treatment and outcomes of a cohort of adults with the Fontan circulation diagnosed with intracardiac thrombus.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S104795110700145X_abs2\" sec-type=\"general\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Formation of thrombus is common after the Fontan operation, albeit little has been published on the treatment and outcomes of these patients once they have developed an intracardiac thrombus.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S104795110700145X_abs3\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>We identified all patients who had been converted to the Fontan circulation from the cardiology database at the Toronto Congenital Cardiac Centre for Adults, Toronto, and The Royal Brompton Hospital, London, studying the period from 1981 to 2003. We then reviewed the relevant echocardiograms and medical records.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S104795110700145X_abs4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Intracardiac thrombus was identified in 28 of 235 patients with the Fontan circulation, the patients having an average age of 27 plus or minus 9 years. Of the patients, 21 were initially medically treated, 19 with heparin or warfarin, and 2 with thrombolysis, whereas 7 patients underwent immediate surgical removal of the clot. Overall mortality was 18%, with residual clots seen in 39% of surviving patients at 1 year of follow up. At presentation, the haemodynamic stability of each patient with intracardiac thrombus dictated initial strategies for management, with 17% of those with stable presentations undergoing immediate surgical treatment, as opposed to 75% of those with unstable presentations (p-value equals 0.04), as well as correlating with ultimate clinical outcome. The rate of death was 8% in haemodynamically stable patients, versus 75% in haemodynamically unstable patients (p value equals 0.01).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S104795110700145X_abs5\" sec-type=\"conclusion\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>Formation of intracardiac thrombus is not rare in adults with the Fontan circulation, and carries a significant risk of death, especially in clinically unstable patients. Emphasis on prevention of formation of the clot is warranted.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s104795110700145x","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T09:26:42Z","timestamp":1193218002000},"page":"646-651","source":"Crossref","is-referenced-by-count":23,"title":["Intracardiac thrombus in adults with the Fontan circulation"],"prefix":"10.1017","volume":"17","author":[{"given":"Wendy","family":"Tsang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Salehian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Gatzoulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Therrien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,10,24]]},"reference":[{"key":"S104795110700145X_manual_ref-6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70310-1"},{"key":"S104795110700145X_manual_ref-4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70311-3"},{"key":"S104795110700145X_manual_ref-3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.2.469"},{"key":"S104795110700145X_manual_ref-15","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V94.9.3007","article-title":"Analysis of warfarin therapy in pediatric patients: a prospective cohort study of 319 patients","volume":"94","author":"Streif","year":"1999","journal-title":"Blood"},{"key":"S104795110700145X_manual_ref-5","first-page":"1125","article-title":"Specific sequelae after Fontan operation at mid- and long-term follow-up. Arrhythmia, liver dysfunction, and coagulation disorders","volume":"106","author":"Comme-Dijkhuis","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S104795110700145X_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03068-5"},{"key":"S104795110700145X_manual_ref-13","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1056\/NEJM198205273062105","article-title":"Thrombolytic therapy","volume":"306","author":"Sharma","year":"1982","journal-title":"N Engl J Med"},{"key":"S104795110700145X_manual_ref-9","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0003-4975(01)02472-9","article-title":"Thrombus formation after the Fontan operation","volume":"71","author":"Coon","year":"2001","journal-title":"Ann Thorac Surg"},{"key":"S104795110700145X_manual_ref-8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0003-4975(02)03677-9","article-title":"Thromboembolic complications after Fontan procedures: comparison of different therapeutic approaches","volume":"74","author":"Seipelt","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"S104795110700145X_manual_ref-12","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(91)90512-8"},{"key":"S104795110700145X_manual_ref-2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.79.3.213"},{"key":"S104795110700145X_manual_ref-11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.287"},{"key":"S104795110700145X_manual_ref-1","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900315"},{"key":"S104795110700145X_manual_ref-14","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70010-9"},{"key":"S104795110700145X_manual_ref-10","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)91924-0"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795110700145X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T05:39:13Z","timestamp":1750484353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795110700145X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,24]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S104795110700145X"],"URL":"https:\/\/doi.org\/10.1017\/s104795110700145x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,24]]}}}