{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:06:30Z","timestamp":1773291990182,"version":"3.50.1"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T00:00:00Z","timestamp":1202256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951108001960_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>The policy of early repair of patients with tetralogy of Fallot, irrespective of age, as opposed to initial palliation with a shunt, remains controversial. The aim of our study was to analyze the midterm outcome of primary early correction of tetralogy of Fallot.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951108001960_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Between 1996 and 2005, a total of 61 consecutive patients less than 6 months of age underwent primary correction of tetralogy of Fallot in two institutions. The median age at surgery was 3.3 months, and 27 patients (44%) were younger than 3 months of age, including 12 (20%) newborns. We analyzed the patients in 2 groups: those younger than 3 months of age, and those aged between 3 and 6 months.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951108001960_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There was one early (1.6%), and one late death. Actuarial survival was 98.4%, 96.7%, 96.7% at 1, 5, and 10 years respectively, with a median follow up of 4.5 years. There was no difference in survival, bypass time, lengths of ventilation, and hospital stay between the groups. A transjunctional patch was placed significantly more often in the patients younger than 3 months (p = 0.039), with no adverse effect on survival and morbidity during the follow-up. Freedom from reoperation was 98.2%, 92.2%, and 83% at 1, 5, and 10 years respectively, with no difference between the groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951108001960_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Elective primary repair of tetralogy of Fallot in asymptomatic patients is delayed beyond 3 months of age. In symptomatic patients, primary repair of tetralogy of Fallot is performed irrespective of age, weight and preoperative state. This approach is safe, and provides an excellent midterm outcome with acceptable morbidity and rates of reintervention. The long-term benefits of this approach must be established by careful follow-up, with particular emphasis on arrhythmias, right ventricular function, and exercise performance.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951108001960","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T10:49:43Z","timestamp":1202294983000},"page":"153-157","source":"Crossref","is-referenced-by-count":22,"title":["Primary early correction of tetralogy of Fallot irrespective of age"],"prefix":"10.1017","volume":"18","author":[{"given":"Andrea","family":"Kantorova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zbieranek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lilje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Haun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Hraska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,2,6]]},"reference":[{"key":"S1047951108001960_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.08.022"},{"key":"S1047951108001960_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.04.016"},{"key":"S1047951108001960_ref15","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.115156"},{"key":"S1047951108001960_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70113-2"},{"key":"S1047951108001960_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.5.1062"},{"key":"S1047951108001960_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.04.001"},{"key":"S1047951108001960_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.suppl_2.II-157"},{"key":"S1047951108001960_ref5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0022-5223(19)34265-5","article-title":"The neonate with critical congenital heart disease: repair, a surgical challenge","volume":"98","author":"Castaneda","year":"1989","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S1047951108001960_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(92)90646-L"},{"key":"S1047951108001960_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00796817"},{"key":"S1047951108001960_ref8","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S0022-5223(19)36968-5","article-title":"Primary repair of tetralogy of Fallot in infancy","volume":"99","author":"Touati","year":"1990","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S1047951108001960_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00732-6"},{"key":"S1047951108001960_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200010000-00006"},{"key":"S1047951108001960_ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2006.02.005"},{"key":"S1047951108001960_ref13","first-page":"206","article-title":"Repair of tetralogy of Fallot in infancy: effect of pulmonary artery size on outcome","volume":"84","author":"Groh","year":"1991","journal-title":"Circulation"},{"key":"S1047951108001960_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90361-K"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951108001960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T14:21:06Z","timestamp":1588342866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951108001960\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S1047951108001960"],"URL":"https:\/\/doi.org\/10.1017\/s1047951108001960","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,6]]}}}