{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:33:23Z","timestamp":1776123203085,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T00:00:00Z","timestamp":1248825600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951109990655_abs1\" sec-type=\"general\"><jats:title>Objectives<\/jats:title><jats:p>Our aims were to estimate the prevalence of increased nuchal translucency in fetuses with a normal karyotype that were subsequently diagnosed with congenital cardiac disease on fetal echocardiography, and to assess whether there is a link between increased nuchal translucency and specific congenital cardiac malformations.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951109990655_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We reviewed all patients referred to King\u2019s College Hospital and the Evelina Children\u2019s Hospital in London for fetal echocardiography between January 1998 and December 2007. We investigated the proportion of chromosomally normal fetuses with congenitally malformed hearts in which nuchal thickness was increased, both overall and with specific defects.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951109990655_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>We indentified 2133 fetuses with congenital cardiac disease by prenatal echocardiography. Of those, 707 were excluded due to abnormal karyotype, and 690 were excluded due to unknown karyotype. The remaining 736 were eligible for inclusion. Among 481 fetuses with documented congenital cardiac disease and normal chromosomes, making up 23% of the overall cohort, 224 had increased nuchal thickness defined as equal or greater than 2.5 millimetres, this being 0.47 of the inclusive cohort, with 95% confidence intervals from 0.42 to 0.51. These proportions were significantly higher than the expected proportion of the normal population, which was 0.05 (p &lt; 0.001). The only diagnosis for which the proportion of fetuses with nuchal translucency measurement equal or greater than 2.5 millimetres was higher than the others was atrioventricular septal defect, with 0.62 of this cohort having abnormal values, with 95% confidence intervals from 0.47 to 0.77 (p = 0.038).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951109990655_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>We found that nearly half of prenatally diagnosed fetuses with congenitally malformed hearts, when examined ultrasonically in the first or early-second trimester, had increased nuchal thickness. We recommend, therefore, referral of all fetuses with increased nuchal translucency for fetal echocardiography.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951109990655","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T05:16:37Z","timestamp":1248844597000},"page":"441-445","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence of increased nuchal translucency in fetuses with congenital cardiac disease and a normal karyotype"],"prefix":"10.1017","volume":"19","author":[{"given":"Melanie","family":"Vogel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurleen K.","family":"Sharland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doff B.","family":"McElhinney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vita","family":"Zidere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen I.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey D.","family":"Allan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"S1047951109990655_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1936"},{"key":"S1047951109990655_ref9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1046\/j.1469-0705.2001.00342.x","article-title":"Limitations of using first-trimester nuchal translucency measurements in routine screening for major congenital heart defects","volume":"17","author":"Marvridis","year":"2001","journal-title":"Ultrasound Obstet Gynecol"},{"key":"S1047951109990655_ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1995.05010020.x"},{"key":"S1047951109990655_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90588-5"},{"key":"S1047951109990655_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7176.81"},{"key":"S1047951109990655_ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00341.x"},{"key":"S1047951109990655_ref18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198711263172203"},{"key":"S1047951109990655_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.06.081"},{"key":"S1047951109990655_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11280-6"},{"key":"S1047951109990655_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90385-0"},{"key":"S1047951109990655_ref17","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.163.3.2953039"},{"key":"S1047951109990655_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2124"},{"key":"S1047951109990655_ref21","first-page":"107","volume-title":"Jahrbuch der Gynaekologie und Geburtshilfe","author":"Gembruch","year":"1991"},{"key":"S1047951109990655_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.05.049"},{"key":"S1047951109990655_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(01)00528-0"},{"key":"S1047951109990655_ref20","first-page":"177","article-title":"Prenatal diagnostizierte Herzfehlbildungen und assoziierte Chromosomenaberrationen","volume":"20","author":"Chaoui","year":"1999","journal-title":"Ultraschall Med"},{"key":"S1047951109990655_ref22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07040245.x"},{"key":"S1047951109990655_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"S1047951109990655_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.093"},{"key":"S1047951109990655_ref2","article-title":"Mortality Statistics. Childhood, infancy and perinatal","volume":"35","year":"2002","journal-title":"Series DH"},{"key":"S1047951109990655_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00172-1"},{"key":"S1047951109990655_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2792"},{"key":"S1047951109990655_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.9.1269"},{"key":"S1047951109990655_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pd.721"},{"key":"S1047951109990655_ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00454.x"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951109990655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T07:10:18Z","timestamp":1556608218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951109990655\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,29]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S1047951109990655"],"URL":"https:\/\/doi.org\/10.1017\/s1047951109990655","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,29]]}}}