{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:37:51Z","timestamp":1778204271132,"version":"3.51.4"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T00:00:00Z","timestamp":1264118400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac rhabdomyomas are benign cardiac tumours with few cardiac complications, but with a known association to tuberous sclerosis that affects the neurologic outcome of the patients. We have analysed the long-term cardiac and neurological outcomes of patients with cardiac rhabdomyomas in order to allow comprehensive prenatal counselling, basing our findings on the records of all patients seen prenatally and postnatally with an echocardiographic diagnosis of cardiac rhabdomyoma encountered from August, 1982, to September, 2007. We analysed factors such as the number and the location of the tumours to establish their association with a diagnosis of tuberous sclerosis, predicting the cardiac and neurologic outcomes for the patients.<\/jats:p><jats:p>Cardiac complications include arrhythmias, obstruction of the ventricular outflow tracts, and secondary cardiogenic shock. Arrhythmias were encountered most often during the neonatal period, with supraventricular tachycardia being the commonest rhythm disturbance identified. No specific dimension or location of the cardiac rhabdomyomas predicted the disturbances of rhythm.<\/jats:p><jats:p>The importance of the diagnosis of tuberous sclerosis is exemplified by the neurodevelopmental complications, with four-fifths of the patients showing epilepsy, and two-thirds having delayed development. The presence of multiple cardiac tumours suggested a higher risk of being affected by tuberous sclerosis. The tumours generally regress after birth, and cardiac-related problems are rare after the perinatal period. Tuberous sclerosis and the associated neurodevelopmental complications dominate the clinical picture, and should form an important aspect of the prenatal counselling of parents.<\/jats:p>","DOI":"10.1017\/s1047951109992046","type":"journal-article","created":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T06:43:38Z","timestamp":1264142618000},"page":"18-24","source":"Crossref","is-referenced-by-count":25,"title":["Considerations for Prenatal Counselling of Patients with Cardiac Rhabdomyomas based on their Cardiac and Neurologic Outcomes"],"prefix":"10.1017","volume":"20","author":[{"given":"Sabrina C.","family":"Degueldre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Chockalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvan","family":"Mivelaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Di Bernardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Pfammatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Barrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Sekarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Jeannet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Fouron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvan","family":"Vial","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik J.","family":"Meijboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,1,22]]},"reference":[{"key":"S1047951109992046_ref38","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200121101"},{"key":"S1047951109992046_ref36","first-page":"131","volume-title":"Diseases of the Nervous System in Childhood","author":"Aicardi","year":"1998"},{"key":"S1047951109992046_ref35","first-page":"1443","article-title":"Primary cardiac tumours: eighteen years of surgical experience on 21 patients","volume":"20","author":"Piazza","year":"2004","journal-title":"Can J Cardiol"},{"key":"S1047951109992046_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00349-9"},{"key":"S1047951109992046_ref31","doi-asserted-by":"publisher","DOI":"10.1157\/13073250"},{"key":"S1047951109992046_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.10.095"},{"key":"S1047951109992046_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1996.tb00499.x"},{"key":"S1047951109992046_ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000021000"},{"key":"S1047951109992046_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/uog.979"},{"key":"S1047951109992046_ref25","first-page":"36","article-title":"Cardiac rhabdomyomas in tuberous sclerosis: clinical symptoms and course in 18 cases diagnosed in childhood","volume":"52","author":"Jimenez Casso","year":"2000","journal-title":"An Esp Pediatr"},{"key":"S1047951109992046_ref21","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-931806"},{"key":"S1047951109992046_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/BF02722750"},{"key":"S1047951109992046_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370402"},{"key":"S1047951109992046_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00677-5"},{"key":"S1047951109992046_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90876-4"},{"key":"S1047951109992046_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/BF02424993"},{"key":"S1047951109992046_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80225-4"},{"key":"S1047951109992046_ref2","first-page":"48","article-title":"Cardiac rhabdomyoma in intrauterine life: clinical features and natural history. 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