{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T04:02:38Z","timestamp":1750564958082,"version":"3.41.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T00:00:00Z","timestamp":1269216000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1047951110000417_abs1\" sec-type=\"general\">\n\t    <jats:title>Objective<\/jats:title>\n\t    <jats:p>To describe the cardiac lesions seen in children with trisomy 21, the outcome of these children and rates of access to corrective surgery at the Bustamante Hospital for Children.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000417_abs2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>A 10-year retrospective review of the records of trisomy 21 patients with cardiac lesions referred to the Bustamante Hospital for Children was conducted.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000417_abs3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>A total of 76 patients were enrolled in the study, 30 (40%) males and 46 (60%) females; among these 110 cardiac lesions were detected. A total of 20 (26%) patients died, 48 (63%) survived, and for 8 (11%) the status was unknown. The most common lesion was the atrioventricular septal defect, which accounted for 41 (37%) of all the lesions and occurred as a single defect in 24 (53%) patients. At presentation, 33 (46%) patients had one or more medical complication; 30 (91%) had cardiac failure, 10 (30%) had pneumonia and 5 (15%) had evidence of systemic pulmonary arterial pressures. Cardiac catheterisation was recommended for 43 (56%) patients but only 10 (23%) had the procedure done. Surgery was recommended for 60 (79%) patients; of these 6 (10%) patients had the procedure done. The median time of survival was 88 months (7.3 years). The age of presentation was not found to significantly affect outcome.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000417_abs4\" sec-type=\"conclusion\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>Trisomy 21 patients with cardiac lesions have high morbidity and mortality. This morbidity and mortality could be reduced if surgical intervention was offered routinely.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1047951110000417","type":"journal-article","created":{"date-parts":[[2010,3,22]],"date-time":"2010-03-22T13:28:33Z","timestamp":1269264513000},"page":"327-331","source":"Crossref","is-referenced-by-count":8,"title":["Congenital cardiovascular lesions in children with trisomy 21 at the Bustamante Hospital for Children"],"prefix":"10.1017","volume":"20","author":[{"given":"Tamra W.","family":"Tomlinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charmaine H.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen L. M.","family":"Trotman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,3,22]]},"reference":[{"key":"S1047951110000417_manual_ref-13","unstructured":"13. Ministry of Health, Jamaica. Bustamante Hospital for Children Monthly Hospital Statistical Report 2004 (unpublished)."},{"key":"S1047951110000417_manual_ref-4","unstructured":"4. Huret, JL , Sinet, PM . Trisomy 21. Atlas Genet Cytogenet Oncol Haematol August, 2000. Available at URL: http:\/\/AtlasGeneticsOncology.org\/Educ\/PolyTri21Eng.html (accessed February, 2005)."},{"key":"S1047951110000417_manual_ref-11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1017\/S1047951105000582","article-title":"Congenital cardiac disease in children with Down\u2019s syndrome in Guatemala","volume":"15","author":"Vida","year":"2005","journal-title":"Cardiol Young"},{"key":"S1047951110000417_manual_ref-3","first-page":"8","volume-title":"Smith\u2019s Recognizable Patterns of Human Malformation","author":"Jones","year":"1997"},{"key":"S1047951110000417_manual_ref-1","unstructured":"1. Leshin, L . The Story of Down Syndrome, 2003. Available at URL: http:\/\/www.ds-health.com (accessed February, 2005)."},{"key":"S1047951110000417_manual_ref-14","first-page":"438","article-title":"Surgical experience with congenital heart disease in Down\u2019s syndrome","volume":"52","author":"Parvathy","year":"2000","journal-title":"Indian Heart J"},{"key":"S1047951110000417_manual_ref-2","unstructured":"2. Benke, PJ , Carver, V , Donahue, R . Risk and Recurrence Risk of Down Syndrome. University of Miami school of Medicine, 1995. Available at URL: http:\/\/www.ds-health.com\/benke.htm (accessed February, 2005)."},{"key":"S1047951110000417_manual_ref-8","first-page":"29","article-title":"Down syndrome with congenital heart malformation","volume":"131","author":"Park","year":"1977","journal-title":"Am J Dis Child"},{"key":"S1047951110000417_manual_ref-10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-5273(98)00354-4","article-title":"Syndromes and malformations associated with congenital heart disease in a population-based study","volume":"68","author":"Grech","year":"1999","journal-title":"Int J Cardiol"},{"key":"S1047951110000417_manual_ref-12","first-page":"128","article-title":"Long term follow up of children with Down syndrome with cardiac lesions","volume":"30","author":"Matthew","year":"1991","journal-title":"Clin Pediatr (Phila)"},{"key":"S1047951110000417_manual_ref-9","first-page":"382","article-title":"Congenital cardiovascular malformations in Chinese children with Down\u2019s syndrome","volume":"102","author":"Lo","year":"1989","journal-title":"Chin Med J (Engl)"},{"key":"S1047951110000417_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.4.822"},{"key":"S1047951110000417_manual_ref-5","first-page":"10","volume-title":"Pediatric Cardiology for Practitioners","author":"Park","year":"2002"},{"key":"S1047951110000417_manual_ref-15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1017\/S1047951107000078","article-title":"Cardiovascular malformations in Omani Arab children with Down\u2019s syndrome","volume":"17","author":"Jaiyesimi","year":"2007","journal-title":"Cardiol Young"},{"key":"S1047951110000417_manual_ref-6","unstructured":"6. The Heart Center Encyclopedia, Cincinatti Children\u2019s posting. Heart Related Syndromes: Down Syndrome (Trisomy 21), 1999. Available at URL: http:\/\/www.cincinnatichildren's.org\/health\/heart-encyclopedia (accessed February, 2005)."}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951110000417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T05:42:33Z","timestamp":1750484553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951110000417\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,22]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1047951110000417"],"URL":"https:\/\/doi.org\/10.1017\/s1047951110000417","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2010,3,22]]}}}