{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:06:53Z","timestamp":1793383613077,"version":"4.5.0"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2010,6,28]],"date-time":"2010-06-28T00:00:00Z","timestamp":1277683200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1047951110000594_abs1\" sec-type=\"general\">\n\t    <jats:title>Objective<\/jats:title>\n\t    <jats:p>To conduct a prospective randomised study to show the efficacy of immune suppression with prednisolone, administered at the 3-month duration of acute myocarditis.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000594_abs2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>The diagnosis of acute viral myocarditis was made based on echocardiography and serum viral antibodies. The inclusion criterion was acute myocarditis of 3 months duration. In all, 68 of 173 children were available for randomisation into a prednisolone-treated group of 44 and a control group of 24 children. The follow-up period in the prednisolone-treated group was 15.1 plus or minus 9.2 months and 13.6 plus or minus 10.6 months for the control group.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000594_abs3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Compared with controls, 1 month after randomisation significantly more children in the prednisolone-treated group increased their ejection fraction to more than 40% (p = 0.029). Discrete analysis of change in the ejection fraction from the one at randomisation to one after 1 month of randomisation of greater than 10% and less than 10% or no change between groups showed a significantly greater number with improvement in the prednisolone-treated group (p = 0.019). At the end of the follow-up visits, a significantly larger number of children in the prednisolone-treated group had an ejection fraction of more than 60% compared with the control group (p = 0.049).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000594_abs4\" sec-type=\"conclusion\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>It is concluded that immune suppression with prednisolone, administered at 3 months of the onset of acute myocarditis, is effective in significantly bringing about improvement and cure in persistent left ventricular failure.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1047951110000594","type":"journal-article","created":{"date-parts":[[2010,6,28]],"date-time":"2010-06-28T12:33:27Z","timestamp":1277728407000},"page":"509-515","source":"Crossref","is-referenced-by-count":44,"title":["Acute viral myocarditis: role of immunosuppression: a prospective randomised study"],"prefix":"10.1017","volume":"20","author":[{"given":"Kalim U.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najma","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareen","family":"Sadullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habiba","family":"Tasneem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasina","family":"Thawerani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Talpur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,6,28]]},"reference":[{"key":"S1047951110000594_manual_ref-3","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80115-9"},{"key":"S1047951110000594_manual_ref-12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00796323"},{"key":"S1047951110000594_manual_ref-10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2006.06.001"},{"key":"S1047951110000594_manual_ref-18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(80)90174-5"},{"key":"S1047951110000594_manual_ref-27","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90834-8"},{"key":"S1047951110000594_manual_ref-17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011093431908"},{"key":"S1047951110000594_manual_ref-5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.2.226"},{"key":"S1047951110000594_manual_ref-24","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.034686"},{"key":"S1047951110000594_manual_ref-32","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e31806450c4"},{"key":"S1047951110000594_manual_ref-34","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00179-0"},{"key":"S1047951110000594_manual_ref-23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.23.2829"},{"key":"S1047951110000594_manual_ref-29","first-page":"637","article-title":"An approach to the treatment of pediatric myocarditis","volume":"4","author":"Levi","year":"2002","journal-title":"Paedtr Drug"},{"key":"S1047951110000594_manual_ref-28","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/16.suppl_O.173"},{"key":"S1047951110000594_manual_ref-20","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00148-S"},{"key":"S1047951110000594_manual_ref-6","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951104005049"},{"key":"S1047951110000594_manual_ref-30","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.026641"},{"key":"S1047951110000594_manual_ref-13","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.4.354"},{"key":"S1047951110000594_manual_ref-2","first-page":"63","article-title":"Acute myocarditis \u2013 the commonest cause of cardiac failure in children","volume":"27","author":"Younas","year":"2003","journal-title":"Pak Paed J"},{"key":"S1047951110000594_manual_ref-22","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00317-3"},{"key":"S1047951110000594_manual_ref-31","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072766.67150.51"},{"key":"S1047951110000594_manual_ref-33","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90013-0"},{"key":"S1047951110000594_manual_ref-4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2582"},{"key":"S1047951110000594_manual_ref-25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.252"},{"key":"S1047951110000594_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021737"},{"key":"S1047951110000594_manual_ref-1","first-page":"121","article-title":"Acute myocarditis in children, incidence, treatment and prognosis. 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