{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:24:41Z","timestamp":1774538681579,"version":"3.50.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T00:00:00Z","timestamp":1274400000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1047951110000727_abs1\" sec-type=\"general\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Complications, such as secondary hypertension, probably related to the loss of arterial elasticity, frequently arise in Cushing\u2019s syndrome, and may persist even beyond cure. This study aimed at demonstrating that arterial compliance, evaluated by automated recording of the QKd interval, was lower in children after a successful surgery for Cushing\u2019s syndrome than in a control group of healthy subjects.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000727_abs2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>In all, 23 young girls aged between 11 and 18 years who had undergone a surgical cure for Cushing syndrome \u2013 18 with a pituitary adenoma, three with a primary adrenal disease, and two suffering from ectopic adrenocorticotrope hormone secretion \u2013 were enrolled. Arterial stiffness was measured by the standardised non-invasive QKd 100-60 method. A 24-hour ambulatory blood pressure monitoring and a transthoracic echocardiography were also performed.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000727_abs3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>The children operated for Cushing\u2019s syndrome showed disadvantageous differences in 24-hour ambulatory blood pressure monitoring and in QKD 100-60 value, with p less than 0.01, compared with the control group.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1047951110000727_abs4\" sec-type=\"conclusion\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>In spite of its successful surgical cure, Cushing\u2019s syndrome results in a significantly decreased arterial distensibility when compared with the control group, which might explain these differences in blood pressure levels. It underlines a significantly higher cardiovascular risk, notwithstanding both the normalisation of cortisol secretion and the very early age of the patients.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1047951110000727","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T10:53:59Z","timestamp":1274439239000},"page":"610-614","source":"Crossref","is-referenced-by-count":14,"title":["Increased arterial rigidity in children affected by Cushing\u2019s syndrome after successful surgical cure"],"prefix":"10.1017","volume":"20","author":[{"given":"Pier Paolo","family":"Bassareo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Raffaele","family":"Marras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Pasqualucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Mercuro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,5,21]]},"reference":[{"key":"S1047951110000727_manual_ref-19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2694"},{"key":"S1047951110000727_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021558"},{"key":"S1047951110000727_manual_ref-9","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.3.591"},{"key":"S1047951110000727_manual_ref-5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800711225"},{"key":"S1047951110000727_manual_ref-6","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-007-0033-8"},{"key":"S1047951110000727_manual_ref-16","first-page":"193","article-title":"Beyond blood pressure measurements: monitoring of the appearance time of Korotkoff sounds","volume":"1","author":"Gosse","year":"1996","journal-title":"Blood Press Monit"},{"key":"S1047951110000727_manual_ref-18","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00239-8"},{"key":"S1047951110000727_manual_ref-2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0125"},{"key":"S1047951110000727_manual_ref-11","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347534"},{"key":"S1047951110000727_manual_ref-20","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199715022-00009"},{"key":"S1047951110000727_manual_ref-3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311002"},{"key":"S1047951110000727_manual_ref-1","first-page":"137","article-title":"The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism)","volume":"50","author":"Cushing","year":"1932","journal-title":"Bull Johns Hopkins Hosp"},{"key":"S1047951110000727_manual_ref-15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.5.920"},{"key":"S1047951110000727_manual_ref-8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030871"},{"key":"S1047951110000727_manual_ref-21","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(96)00494-3"},{"key":"S1047951110000727_manual_ref-22","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-005-0013-4"},{"key":"S1047951110000727_manual_ref-4","first-page":"2664","article-title":"Persistence of increased cardiovascular risk in patients with Cushing\u2019s disease after five years of successful cure","volume":"84","author":"Colao","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"S1047951110000727_manual_ref-14","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/7.3.228"},{"key":"S1047951110000727_manual_ref-10","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1588"},{"key":"S1047951110000727_manual_ref-17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.4.613"},{"key":"S1047951110000727_manual_ref-12","first-page":"18","article-title":"24-hours profiles of blood pressure and heart rate in Cushing\u2019s syndrome. Evidence for differential control of cardiovascular variables by glucocorticoids","volume":"5","author":"Panarelli","year":"1990","journal-title":"Ann Ital Med Int"},{"key":"S1047951110000727_manual_ref-13","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00299-5"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951110000727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T03:45:09Z","timestamp":1750477509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951110000727\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,21]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S1047951110000727"],"URL":"https:\/\/doi.org\/10.1017\/s1047951110000727","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,21]]}}}