{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:38:49Z","timestamp":1769636329790,"version":"3.49.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T00:00:00Z","timestamp":1292976000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951110001678_abs1\" sec-type=\"general\"><jats:title>Objectives<\/jats:title><jats:p>Although magnetic resonance imaging is a primary modality for following patients with connective tissue diseases, only a limited amount of the image data is utilised. The purpose of this study was to show the clinical applicability of an automated four-dimensional analysis method of magnetic resonance images of the aorta and develop normative data for the cross-sectional area of the entire thoracic aorta.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951110001678_abs2\" sec-type=\"general\"><jats:title>Study design<\/jats:title><jats:p>Magnetic resonance imaging was obtained serially over 3 years from 32 healthy individuals and 24 patients with aortopathy and a personal or family history of connective tissue disorder. Graph theory-based segmentation was used to determine the cross-sectional area for the thoracic aorta. Healthy individual data were used to construct a nomogram representing the maximum cross-sectional area 5th\u201395th percentile along the entire thoracic aorta. Aortic root diameters calculated from the cross-sectional area were compared to measured diameters from echocardiographic data. The cross-sectional area of the entire thoracic aorta in patients was compared to healthy individuals.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951110001678_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Calculated aortic root diameters correlated with measured diameters from echo data \u2013 correlation coefficient was 0.74\u20130.87. The cross-sectional area in patients was significantly greater in the aortic root, ascending aorta, and descending aorta compared to healthy individuals.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951110001678_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>The presentation of the dimensional data for the entire thoracic aorta shows an important clinical tool for following patients with connective tissue disorders and aortopathy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951110001678","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T11:07:52Z","timestamp":1294225672000},"page":"170-177","source":"Crossref","is-referenced-by-count":4,"title":["Quantitative assessment of the entire thoracic aorta from magnetic resonance images"],"prefix":"10.1017","volume":"21","author":[{"given":"Ryan K.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthil","family":"Premraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali S.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Wahle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Stolpen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Sonka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,12,22]]},"reference":[{"key":"S1047951110001678_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2007.02.005"},{"key":"S1047951110001678_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.01.034"},{"key":"S1047951110001678_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.081638"},{"key":"S1047951110001678_ref7","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1056\/NEJM199904293401710","article-title":"Aortic disease in Marfan\u2019s syndrome","volume":"340","author":"Roman","year":"1999","journal-title":"N Engl J Med"},{"key":"S1047951110001678_ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904293401702"},{"key":"S1047951110001678_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-010-9592-5"},{"key":"S1047951110001678_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.04.033"},{"key":"S1047951110001678_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2009.02.005"},{"key":"S1047951110001678_ref10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006429603062"},{"key":"S1047951110001678_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90430-X"},{"key":"S1047951110001678_ref6","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJM199904293401702","article-title":"Replacement of the aortic root in patients with Marfan\u2019s syndrome","volume":"340","author":"Pyeritz","year":"1999","journal-title":"N Engl J Med"},{"key":"S1047951110001678_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.03.019"},{"key":"S1047951110001678_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.020"},{"key":"S1047951110001678_ref14","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.203.3.9169695"},{"key":"S1047951110001678_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.3.728"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951110001678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T19:00:10Z","timestamp":1556391610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951110001678\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,22]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S1047951110001678"],"URL":"https:\/\/doi.org\/10.1017\/s1047951110001678","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,22]]}}}