{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:55:33Z","timestamp":1762865733158},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T00:00:00Z","timestamp":1295913600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2011,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Remote ischaemic pre-conditioning and cardiac ischaemic post-conditioning provide myocardial protection in cardiac surgery. However, these two endogenous strategies have not been directly compared in a clinical setting. The purpose of this study was to compare the efficacy of remote ischaemic pre-conditioning and post-conditioning in providing myocardial protection to children undergoing cardiopulmonary bypass for surgical repair of ventricular septal defect.<\/jats:p><\/jats:sec>Methods<\/jats:title>We randomly assigned 60 paediatric patients scheduled for surgical correction of congenital ventricular septal defect to the post-conditioning group (n = 20), remote pre-conditioning group (n = 20), or control group (n = 20). Post-conditioning consisted of 30 seconds of ischaemia and 30 seconds of reperfusion achieved by clamping and unclamping the aorta, repeated three times over 3 minutes immediately after cardioplegic arrest. Remote ischaemic pre-conditioning consisted of 5 minutes of lower limb ischaemia followed by 5 minutes of reperfusion using a blood-pressure cuff inflated to a pressure of 200 millimetres of mercury, also repeated three times over 30 minutes. We assayed creatine kinase-MB, troponin I.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean age, cardiopulmonary bypass times, and aortic cross-clamp times were matched across groups. Both post-conditioning and remote ischaemic pre-conditioning reduced the peak release of creatine kinase-MB (86.1 plus or minus 24.1 units per litre and 92.8 plus or minus 20.6 units per litre, respectively, versus 111.0 plus or minus 44.6 units per litre in the control, p less than 0.05) and troponin I (0.28 plus or minus 0.10 nanogram per millilitre and 0.26 plus or minus 0.09 nanogram per millilitre, respectively, versus 0.49 plus or minus 0.19 nanogram per millilitre in the control group, p less than 0.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study demonstrates that ischaemic post-conditioning and remote ischaemic pre-conditioning provide comparable myocardial benefit in children undergoing cold blood cardioplegic arrest.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951110001915","type":"journal-article","created":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T09:54:15Z","timestamp":1295949255000},"page":"266-270","source":"Crossref","is-referenced-by-count":32,"title":["A comparison of cardiac post-conditioning and remote pre-conditioning in paediatric cardiac surgery"],"prefix":"10.1017","volume":"21","author":[{"given":"Wanjun","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangde","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,1,25]]},"reference":[{"key":"S1047951110001915_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.03.017"},{"key":"S1047951110001915_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61296-3"},{"key":"S1047951110001915_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951108002072"},{"key":"S1047951110001915_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000041430.32233.5B"},{"key":"S1047951110001915_ref10","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2008.189373"},{"key":"S1047951110001915_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.155770"},{"key":"S1047951110001915_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.066"},{"key":"S1047951110001915_ref2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01064.2002"},{"key":"S1047951110001915_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.11.010"},{"key":"S1047951110001915_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.679167"},{"key":"S1047951110001915_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.01.028"},{"key":"S1047951110001915_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.02.014"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951110001915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T08:31:12Z","timestamp":1556353872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951110001915\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,25]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1047951110001915"],"URL":"https:\/\/doi.org\/10.1017\/s1047951110001915","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,25]]}}}