{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:50:38Z","timestamp":1790070638176,"version":"4.0.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T00:00:00Z","timestamp":1307491200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951111000497_abs1\" sec-type=\"general\"><jats:title>Objectives<\/jats:title><jats:p>This study evaluates the efficacy and safety of sildenafil in patients with Eisenmenger's syndrome with special emphasis on haemodynamic parameters and its comparative efficacy in atrial septal defect versus ventricular septal defect patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111000497_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Oral sildenafil was given to 22 patients with Eisenmenger's syndrome \u2013 eight with atrial septal defect and 14 with ventricular septal defect \u2013 after detailed baseline evaluation including a six-minute walk test, echocardiography, and cardiac catheterisation. Patients were followed up for a period of 6 months for functional class assessment and six-minute walk distance. Cardiac catheterisation was repeated in all patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111000497_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A significant improvement in the World Health Organization functional class, six-minute walk distance, mean pulmonary arterial pressure, and pulmonary vascular resistance was noticed. Systemic arterial and mixed venous oxygen saturations were also significantly improved along with improvement in pulmonary blood flow. None showed any significant side effects or worsening of systemic arterial saturation. At baseline, mean pulmonary arterial pressure, pulmonary vascular resistance, and pulmonary\/systemic vascular resistance ratios were significantly higher in ventricular septal defect patients than in atrial septal defect patients. Atrial septal defect patients showed better response in clinical as well as haemodynamic parameters.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111000497_abs4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Sildenafil is an effective and safe agent for patients with Eisenmenger's syndrome. It improves their functional capacity as well as haemodynamic parameters. The beneficial effects are greater in patients with Eisenmenger's syndrome secondary to atrial septal defect than ventricular septal defect.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951111000497","type":"journal-article","created":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T05:34:58Z","timestamp":1307511298000},"page":"631-638","source":"Crossref","is-referenced-by-count":13,"title":["Comparative efficacy of sildenafil in Eisenmenger's syndrome secondary to atrial septal defect versus ventricular septal defect: a cardiac catheterisation follow-up study"],"prefix":"10.1017","volume":"21","author":[{"given":"Naveen","family":"Garg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Tripathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakul","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,6,8]]},"reference":[{"key":"S1047951111000497_ref18","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.2.9906015"},{"key":"S1047951111000497_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951107001849"},{"key":"S1047951111000497_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005082-200503000-00008"},{"key":"S1047951111000497_ref14","first-page":"342","article-title":"Sildenafil for pulmonary hypertension secondary to congenital heart diseases","volume":"59","author":"Gupta","year":"2007","journal-title":"Indian Heart J"},{"key":"S1047951111000497_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.04.037"},{"key":"S1047951111000497_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.10.056"},{"key":"S1047951111000497_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.097360"},{"key":"S1047951111000497_ref3","first-page":"421","article-title":"Eisenmenger syndrome in the adults- experience with new drugs for the treatment of pulmonary hypertension","volume":"24","author":"Agapito","year":"2005","journal-title":"Rev Port Cardiol"},{"key":"S1047951111000497_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl017"},{"key":"S1047951111000497_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00420-X"},{"key":"S1047951111000497_ref20","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592386"},{"key":"S1047951111000497_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.603001"},{"key":"S1047951111000497_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.06.045"},{"key":"S1047951111000497_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000125148.82698.65"},{"key":"S1047951111000497_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.crd.0000181618.29506.1e"},{"key":"S1047951111000497_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.09.006"},{"key":"S1047951111000497_ref10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.20.13729"},{"key":"S1047951111000497_ref19","first-page":"148","volume-title":"Grossman's Cardiac Catheterization, Angiography and Intervention","author":"Grossman","year":"2006"},{"key":"S1047951111000497_ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050010"},{"key":"S1047951111000497_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2003.12.023"},{"key":"S1047951111000497_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.10.017"},{"key":"S1047951111000497_ref13","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.461"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951111000497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T21:11:21Z","timestamp":1556313081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951111000497\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,8]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,10,28]]}},"alternative-id":["S1047951111000497"],"URL":"https:\/\/doi.org\/10.1017\/s1047951111000497","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,8]]}}}