{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:23:18Z","timestamp":1781079798611,"version":"3.54.1"},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T00:00:00Z","timestamp":1311206400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report an infantile case of Loeys\u2013Dietz syndrome prenatally diagnosed with congenital complex heart disease \u2013 double outlet right ventricle and interruption of the aortic arch. The patient also showed prominent dilatation of the main pulmonary artery. Emergency bilateral pulmonary artery banding was performed on the 9th day. However, on the 21st day, the patient died of massive bleeding due to rupture of the right pulmonary artery. Subsequently, a mutation of the TGFBR1 gene was detected. As cardiovascular lesions of Loeys\u2013Dietz syndrome appear early and progress rapidly, the prognosis is generally poor. Patients require periodic examination and early intervention with medical therapy such as Losartan administration and surgical therapy. Early genetic screening is thought to be useful for the prediction of complications as well as vascular disease.<\/jats:p>","DOI":"10.1017\/s1047951111001028","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T05:56:26Z","timestamp":1311227786000},"page":"116-119","source":"Crossref","is-referenced-by-count":15,"title":["Prenatal complex congenital heart disease with Loeys\u2013Dietz syndrome"],"prefix":"10.1017","volume":"22","author":[{"given":"Yukiko","family":"Kawazu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Inamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futoshi","family":"Kayatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Morisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,7,21]]},"reference":[{"key":"S1047951111001028_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1565"},{"key":"S1047951111001028_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33263"},{"key":"S1047951111001028_ref4","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.1833"},{"key":"S1047951111001028_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1511"},{"key":"S1047951111001028_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ng1392"},{"key":"S1047951111001028_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055695"},{"key":"S1047951111001028_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32567"},{"key":"S1047951111001028_ref5","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0757"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951111001028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T21:51:23Z","timestamp":1556229083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951111001028\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,21]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1047951111001028"],"URL":"https:\/\/doi.org\/10.1017\/s1047951111001028","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,21]]}}}