{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:04:54Z","timestamp":1790186694153,"version":"4.1.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2011,7,27]],"date-time":"2011-07-27T00:00:00Z","timestamp":1311724800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951111001053_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Cardiovascular complications and vascular changes are common in patients with beta-thalassaemia major. The aim of this study is to investigate the common carotid artery intima-media thickness in children.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111001053_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The study population was consisted of 33 thalassaemic children (22 boys and 11 girls, with a median age of 8 years) and 30 healthy children for control (12 girls and 18 boys, with a median age of 8 years) who were matched for age and gender. Common carotid artery intima-media thickness of the children was measured.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111001053_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The patients\u2019 age at diagnosis ranged from 0.25 to 2 years, with a median of 0.6 months. Their disease duration ranged from 4 to 13.75 years, with a median of 6.5 years. The patients\u2019 median common carotid artery intima-media thickness was significantly higher than controls \u2013 that is, 0.87 versus 0.74, with a p-value less than 0.005. The mean common carotid artery intima-media thickness value was positively correlated with disease duration (r = 0.535), with a p-value less than 0.01 and ferritin level (r = 0.501), with a p-value less than 0.01.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111001053_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Owing to the nature of the disease, patients with beta-thalassaemia major should be considered to have an increased risk of early vascular alteration and atherosclerosis. For this reason, common carotid artery intima-media thickness measurement can be recommended as a non-invasive and early diagnostic method.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951111001053","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T05:05:44Z","timestamp":1311915944000},"page":"79-83","source":"Crossref","is-referenced-by-count":15,"title":["The evaluation of carotid intima-media thickness in children with beta-thalassaemia major"],"prefix":"10.1017","volume":"22","author":[{"given":"Mustafa","family":"Dogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvan 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