{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T05:53:16Z","timestamp":1726206796429},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951111001946_abs1\" sec-type=\"intro\"><jats:title>Introduction<\/jats:title><jats:p>Propranolol was recently discovered to be an effective treatment for infantile haemangiomas, and varying doses and monitoring regimens have been proposed. Adverse events, although uncommon, have been reported.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111001946_abs2\" sec-type=\"materialsandmethods\"><jats:title>Materials and methods<\/jats:title><jats:p>This was a retrospective chart review of infants with haemangiomas who were started on propranolol at a dose of 3 milligrams per kilogram per day on an outpatient basis. After a baseline cardiac evaluation including an electrocardiogram and an echocardiogram, treatment was initiated during 6 hours of observation.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111001946_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 15 patients were identified; however, only 13 returned for at least one follow-up visit. This cohort was followed up for a median of 2.8 months with a range from 0.2 to 10.0. No hypotension, hypoglycaemia, bronchospasm, or clinically significant bradycardia occurred during treatment. All patients had clinical improvement of their haemangiomas.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951111001946_abs4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that initiating treatment during outpatient observation may be a reasonable alternative to inpatient admission. In addition, expensive testing may not be necessary during pre-treatment screening when the physical examination is normal.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951111001946","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T13:33:00Z","timestamp":1323869580000},"page":"424-429","source":"Crossref","is-referenced-by-count":12,"title":["Propranolol for infantile haemangiomas: initiating treatment on an outpatient basis"],"prefix":"10.1017","volume":"22","author":[{"given":"Joshua L.","family":"Dyme","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashis","family":"Thampan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia J.","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Themba L.","family":"Nyirenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohy E.","family":"Kotb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen T.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"S1047951111001946_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.158"},{"key":"S1047951111001946_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00975.x"},{"key":"S1047951111001946_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/0194599810390445"},{"key":"S1047951111001946_ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1013217"},{"key":"S1047951111001946_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3182152e4e"},{"key":"S1047951111001946_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09848.x"},{"key":"S1047951111001946_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01224.x"},{"key":"S1047951111001946_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708819"},{"key":"S1047951111001946_ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2767"},{"key":"S1047951111001946_ref7","volume-title":"The Harriet Lane Handbook: a Manual for Pediatric House Officers","author":"Custer","year":"2009"},{"key":"S1047951111001946_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20807"},{"key":"S1047951111001946_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80096-1"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951111001946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T19:15:36Z","timestamp":1556219736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951111001946\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,14]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1047951111001946"],"URL":"https:\/\/doi.org\/10.1017\/s1047951111001946","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,14]]}}}