{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:25:47Z","timestamp":1777116347897,"version":"3.51.4"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T00:00:00Z","timestamp":1329782400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951112000029_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Treatment of patent foramen ovale in young patients with stroke is not supported by robust scientific evidence. In clinical practice, a pragmatic approach is needed to guide such therapeutic decisions. This study aims at standardising the diagnostic pathway for stroke patients younger than 55 years of age with a patent foramen ovale; elaborating a therapeutic algorithm; discussing every case in regular interdisciplinary counselling meeting; and setting up a follow-up schedule to assess clinical outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951112000029_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This is a cohort study on the effect of a standardised treatment of stroke patients with a patent foramen ovale. The primary endpoints include occurrence of recurrent ischaemic events, major bleeding, and device-related complications. The secondary endpoints include drug- or procedure-related side effects, persistence of right-to-left shunt, and persistent cardiac arrhythmia of new onset.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951112000029_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 103 patients have been enrolled. In all, 51 patients underwent percutaneous atrial septal repair; of these, one had minor post-procedural bleeding. At 12 months, 25% of this group of patients showed a latent I grade shunt, one patient a latent II degree shunt, and none had a persistent shunt. The remaining 52 patients were addressed to medical therapy; one of them experienced stroke recurrences while on medical therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951112000029_abs4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>This model of implementation of available evidence to clinical practice via a group-based, multi-disciplinary counselling provides a shared and coherent decision pathway and yielded a very low rate of recurrent events and therapy-related complications. This approach could be replicated in specific protocols for other complex or neglected clinical problems.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951112000029","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T09:32:46Z","timestamp":1329816766000},"page":"327-334","source":"Crossref","is-referenced-by-count":11,"title":["A model of multi-disciplinary approach to the diagnosis and treatment of young patients with cryptogenic stroke and patent foramen ovale"],"prefix":"10.1017","volume":"22","author":[{"given":"Sara","family":"Mazzucco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bovi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Carletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Tomelleri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Golia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Stegagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Variola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Anselmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Nicolis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Olivato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Paolo","family":"Anzola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Ribichini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the VEROSTROKE Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,2,21]]},"reference":[{"key":"S1047951112000029_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.06.026"},{"key":"S1047951112000029_ref37","first-page":"3143","article-title":"(Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"S1047951112000029_ref34","first-page":"1462","article-title":"2007 Guidelines for the management of arterial hypertension","volume":"28","year":"2007","journal-title":"Eur Heart J"},{"key":"S1047951112000029_ref32","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000137764.07815.de"},{"key":"S1047951112000029_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410250410"},{"key":"S1047951112000029_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.044"},{"key":"S1047951112000029_ref22","unstructured":"22. 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