{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:45:47Z","timestamp":1756309547513},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951112000480_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>The fate of right ventricular dimensions after surgical closure of secundum-type atrial septal defects remains unclear. The objectives of this study were to assess ventricular dimensions, exercise capability, and arrhythmias of patients operated for secundum-type atrial septal defect and compare the results with those in healthy references.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951112000480_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A total of 78 consecutive patients underwent surgical closure for a secundum-type atrial septal defect between 1990 and 1995. In all, 42 patients were included and underwent a cross-sectional evaluation including echocardiography, magnetic resonance imaging, exercise testing, and 24-hour ambulatory electrocardiography. Patients were matched with healthy controls for gender, body surface area, and age.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951112000480_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The mean age at surgery was 4.6 plus or minus 2.8 years, and the mean age at follow-up was 16 plus or minus 3 years. There were no residual intracardiac lesions. The mean right ventricular end-systolic volume was significantly larger in patients (142 \u00b1 26 millilitres) than in references (137 \u00b1 28 millilitres; p = 0.04). In 25% of the patients, right ventricular end-systolic volume was larger than the 95th percentile for references. No relevant arrhythmias were detected. Exercise testing did not reveal differences with healthy references: maximal power (169 \u00b1 43 Watt patients versus 172 \u00b1 53 controls; p = 0.8), maximal oxygen uptake (38 \u00b1 8 versus 41 \u00b1 13 millilitres per minute per kilogram; p = 0.1).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951112000480_abs4\" sec-type=\"general\"><jats:title>Comment<\/jats:title><jats:p>After surgical closure of secundum-type atrial septal defect, right ventricular end-systolic volume is increased. These findings have no impact on rhythm status or exercise capacity at this stage of follow-up, but may have implications for the timing of surgery or the technique of closure if confirmed in longer follow-up.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951112000480","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T09:04:02Z","timestamp":1334653442000},"page":"7-13","source":"Crossref","is-referenced-by-count":11,"title":["Enlarged right ventricular size at 11 years\u2019 follow-up after closure of secundum-type atrial septal defect in children"],"prefix":"10.1017","volume":"23","author":[{"given":"Wilfred B.","family":"de Koning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennie M.","family":"van 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