{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:15:08Z","timestamp":1790648108993,"version":"4.1.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic>Early detection of cardiovascular disease in children with end-stage renal disease is essential in order to prevent cardiovascular morbidity and mortality in early adulthood. Tissue Doppler imaging has shown to be a promising method to detect and quantify subtle abnormalities in diastolic function. We therefore compared assessment of diastolic function by conventional echocardiography and tissue Doppler imaging.<jats:italic>Methods:<\/jats:italic>We performed conventional echocardiography and tissue Doppler imaging in 38 children with end-stage renal disease and 76 healthy controls. We compared outcomes on parameters related to diastolic function (E\/a ratio for conventional echocardiography and E\/E\u2032 ratio for tissue Doppler imaging) for both groups using multiple linear regression analysis. Diastolic dysfunction was defined as E\/a ratio &lt;1 or E\/E\u2032 ratio &gt; 95th percentile for age. To assess the intra-observer reproducibility, the coefficient of variation was calculated.<jats:italic>Results<\/jats:italic>: Children with end-stage renal disease had on average a lower E\/a ratio (p = 0.004) and a higher mitral and septal E\/E\u2032 ratio (both p &lt; 0.001) compared with controls. In all, two children with end-stage renal disease (5%) had diastolic dysfunction according to the E\/a ratio, 11 according to the mitral E\/E\u2032 ratio (29%), and 16 according to the septal E\/E\u2032 ratio (42%) compared with none of the controls (p = 0.109, p &lt; 0.001, and p &lt; 0.001, respectively). The coefficients of variation of the mitral (7%) and septal E\/E\u2032 ratio (4%) were smaller than the coefficient of variation of the E\/a ratio (11%).<jats:italic>Conclusions:<\/jats:italic>Tissue Doppler imaging is a more sensitive and reliable method to detect diastolic dysfunction than conventional E\/a ratio in children with end-stage renal disease.<\/jats:p>","DOI":"10.1017\/s1047951113000188","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T16:44:22Z","timestamp":1362501862000},"page":"236-244","source":"Crossref","is-referenced-by-count":18,"title":["Diastolic dysfunction measured by tissue Doppler imaging in children with end-stage renal disease: a report of the RICH-Q study"],"prefix":"10.1017","volume":"24","author":[{"given":"Nikki J.","family":"Schoenmaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Kuipers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna H.","family":"van der Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma F.","family":"Tromp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"van Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Gewillig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico A.","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap W.","family":"Groothoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"S1047951113000188_ref19","first-page":"S77","article-title":"Echocardiographic assessment of cardiac function in children with chronic renal failure","volume":"15","author":"O'Regan","year":"1983","journal-title":"Kidney Int Suppl"},{"key":"S1047951113000188_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.09.001"},{"key":"S1047951113000188_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1788"},{"key":"S1047951113000188_ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.716647"},{"key":"S1047951113000188_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0359-0"},{"key":"S1047951113000188_ref7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijcard.2011.10.119","article-title":"Statement on authorship and publishing ethics in the International Journal of Cardiology","volume":"153","author":"Coats","year":"2011","journal-title":"Int J Cardiol"},{"key":"S1047951113000188_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.03.108"},{"key":"S1047951113000188_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq591"},{"key":"S1047951113000188_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.07.021"},{"key":"S1047951113000188_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp049"},{"key":"S1047951113000188_ref14","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1542\/peds.98.4.649","article-title":"Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program","volume":"98","year":"1996","journal-title":"Pediatrics"},{"key":"S1047951113000188_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00525.x"},{"key":"S1047951113000188_ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00156.x"},{"key":"S1047951113000188_ref33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00565.x"},{"key":"S1047951113000188_ref23","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11411210"},{"key":"S1047951113000188_ref18","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1177\/089686080502503S32","article-title":"Cardiovascular disease as a late complication of end-stage renal disease in children","volume":"25","author":"Groothoff","year":"2005","journal-title":"Perit Dial Int"},{"key":"S1047951113000188_ref4","doi-asserted-by":"crossref","unstructured":"Schoenmaker NJ , van der Lee JH , Groothoff J , et al. 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