{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:37:15Z","timestamp":1781534235105,"version":"3.54.5"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction:<\/jats:italic> Ischaemia-modified albumin, a novel biochemical marker for tissue ischaemia, was found to be associated with oxidative stress. The purpose of this study was to assess the role of ischaemia-modified albumin in the diagnosis of acute rheumatic fever and also to evaluate the ischaemia-modified albumin levels in children with heart valve disease. <jats:italic>Methods:<\/jats:italic> The study groups, aged 5\u201318 years, consisted of 128 individuals \u2013 40 with acute rheumatic fever, 35 with congenital heart valve disease, 33 with chronic rheumatic heart disease, and 20 healthy control subjects. <jats:italic>Results:<\/jats:italic> The ischaemia-modified albumin, erythrocyte sedimentation rate, and C-reactive protein levels of the acute rheumatic fever group were significantly higher than those in the chronic rheumatic heart disease, congenital heart valve disease, and control groups, separately (p &lt; 0.001). The ischaemia-modified albumin levels in both carditis and isolated arthritis subgroups of children with acute rheumatic fever were significantly higher than in the control group (p &lt; 0.001, p &lt; 0.01, respectively). However, there was no statistically significant difference between the chorea subgroup and control subjects. In addition, significant correlations were observed between ischaemia-modified albumin and acute phase reactants of patients with acute rheumatic fever (p &lt; 0.001 for both erythrocyte sedimentation rate and C-reactive protein). The ischaemia-modified albumin levels of chronic rheumatic heart disease, congenital heart valve disease, and control subjects were similar. <jats:italic>Conclusions:<\/jats:italic> The increased level of ischaemia-modified albumin in children with acute rheumatic fever seems to be associated with inflammation. However, further studies are needed to provide stronger evidence.<\/jats:p>","DOI":"10.1017\/s1047951113000516","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T10:15:09Z","timestamp":1368180909000},"page":"430-436","source":"Crossref","is-referenced-by-count":8,"title":["Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever"],"prefix":"10.1017","volume":"24","author":[{"given":"Zehra","family":"Karata\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Baysal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"\u015eap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrullah","family":"Alp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idris","family":"Mehmeto\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"key":"S1047951113000516_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.04.012"},{"key":"S1047951113000516_ref24","doi-asserted-by":"publisher","DOI":"10.1258\/000456307779596057"},{"key":"S1047951113000516_ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2001.01846.x"},{"key":"S1047951113000516_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.11.018"},{"key":"S1047951113000516_ref28","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.1.92"},{"key":"S1047951113000516_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3282a66099"},{"key":"S1047951113000516_ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.11.1522"},{"key":"S1047951113000516_ref37","first-page":"536","article-title":"Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease","volume":"36","author":"Rabus","year":"2008","journal-title":"Turk Kardiyol Dern Ars"},{"key":"S1047951113000516_ref5","first-page":"685","article-title":"Pathology and pathogenesis of rheumatic heart disease","volume":"50","author":"Chopra","year":"2007","journal-title":"Indian J Pathol Microbiol"},{"key":"S1047951113000516_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2010.00916.x"},{"key":"S1047951113000516_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/BF02722592"},{"key":"S1047951113000516_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20799"},{"key":"S1047951113000516_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000227513.13697.ac"},{"key":"S1047951113000516_ref36","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.333"},{"key":"S1047951113000516_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.049643"},{"key":"S1047951113000516_ref3","first-page":"251","article-title":"Contribution of selected serum inflammatory mediators to the progression of chronic rheumatic valve disease, subsequent valve calcification and NYHA functional class","volume":"14","author":"Davutoglu","year":"2005","journal-title":"J Heart Valve Dis"},{"key":"S1047951113000516_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951101000300"},{"key":"S1047951113000516_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.074"},{"key":"S1047951113000516_ref23","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.078089"},{"key":"S1047951113000516_ref18","unstructured":"Rheumatic fever and rheumatic heart disease, World Health Organ Tech Rep Ser, 2004; 923: 1\u2013122."},{"key":"S1047951113000516_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.09.015"},{"key":"S1047951113000516_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(02)00102-2"},{"key":"S1047951113000516_ref11","doi-asserted-by":"publisher","DOI":"10.2143\/AC.65.1.2045889"},{"key":"S1047951113000516_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.01.031"},{"key":"S1047951113000516_ref10","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.037"},{"key":"S1047951113000516_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.01.010"},{"key":"S1047951113000516_ref34","doi-asserted-by":"publisher","DOI":"10.1017\/S104795110200094X"},{"key":"S1047951113000516_ref30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803177"},{"key":"S1047951113000516_ref27","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.034371"},{"key":"S1047951113000516_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"S1047951113000516_ref16","doi-asserted-by":"crossref","unstructured":"Guidelines for the diagnosis of rheumatic fever. 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