{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:32:27Z","timestamp":1768311147074,"version":"3.49.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951113001376_abs1\" sec-type=\"intro\"><jats:title>Introduction<\/jats:title><jats:p>Stenosis, mediated by neointimal hyperplasia and thrombosis, is a major limiting factor in successful stent implantation. The introduction of a stent, coated in its endoluminal surface by antihuman CD34 antibodies with endothelial progenitor cell-capturing properties, opens the possibility of promoting a rapid and normal functioning coverage by endothelium and thus avoids both an excessive cell proliferation within stent and the need for long-term dual antiplatelet therapy. These stents, developed for adult coronary artery disease, have not yet been implanted in children or in those with congenital heart disease.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951113001376_abs2\" sec-type=\"general\"><jats:title>Objective and methods<\/jats:title><jats:p>In this paper, we describe the implantation of Genous<jats:sup>\u00ae<\/jats:sup>stents in three children with cyanotic congenital heart disease and obstructed systemic-to-pulmonary shunts. We describe the use of this stent and address its potential feasibility in paediatric congenital heart disease.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951113001376_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>To maintain the patency of two modified Blalock\u2013Taussig shunts and one ductus arteriosus, four Genous<jats:sup>\u00ae<\/jats:sup>stents were implanted in three infants with cyanotic heart disease. All procedures were immediately successful, with resolution of stenosis and improvement in transcutaneous oxygen saturation from 66% \u00b1 3.6% to 92% \u00b1 2.6%. In the follow-up, one stent had no occlusion; however, the remaining two had partial occlusion after 5 and 5.5 months, which were successfully managed with balloon dilatation preceding elective definitive surgical correction.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951113001376_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>In our preliminary experience, we demonstrated that Genous<jats:sup>\u00ae<\/jats:sup>stent implantation was feasible in infants with complex congenital heart disease. Additional studies with larger samples and longer follow-up are required to confirm the potential benefits of this technology in this clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951113001376","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T04:47:52Z","timestamp":1379479672000},"page":"900-904","source":"Crossref","is-referenced-by-count":5,"title":["Initial use of endothelial progenitor cells capturing stents in paediatric congenital heart disease"],"prefix":"10.1017","volume":"24","author":[{"given":"Nuno","family":"Cabanelas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 D. F.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1tima","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"S1047951113001376_ref19","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV6I7A141"},{"key":"S1047951113001376_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.09.015"},{"key":"S1047951113001376_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2008.00197.x"},{"key":"S1047951113001376_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp476"},{"key":"S1047951113001376_ref18","first-page":"350","article-title":"Accelerated vascular repair following percutaneous coronary intervention by capture of endothelial progenitor cells promotes regression of neointimal growth at long-term follow-up: final results of HEALING II trial using an endothelial progenitor cell capturing stent (Genous R stent\u00ae)","volume":"3","author":"Duckers","year":"2007","journal-title":"Euro Intervention"},{"key":"S1047951113001376_ref13","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2009.219741"},{"key":"S1047951113001376_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.123000"},{"key":"S1047951113001376_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2007.00095.x"},{"key":"S1047951113001376_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2009.00364.x"},{"key":"S1047951113001376_ref27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121732.85572.6F"},{"key":"S1047951113001376_ref5","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32833a070d"},{"key":"S1047951113001376_ref1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1017\/S1047951100007150","article-title":"Results of 546 Blalock\u2013Taussig shunts performed in 478 patients","author":"Al Jubair","year":"1998","journal-title":"Cardiol Young"},{"key":"S1047951113001376_ref20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.3.224"},{"key":"S1047951113001376_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03407.x"},{"key":"S1047951113001376_ref31","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23076"},{"key":"S1047951113001376_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2010.00576.x"},{"key":"S1047951113001376_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951108001959"},{"key":"S1047951113001376_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21448"},{"key":"S1047951113001376_ref9","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.41054"},{"key":"S1047951113001376_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951108002424"},{"key":"S1047951113001376_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.048"},{"key":"S1047951113001376_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.1.44"},{"key":"S1047951113001376_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951111000254"},{"key":"S1047951113001376_ref30","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20851"},{"key":"S1047951113001376_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-009-1219-1"},{"key":"S1047951113001376_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.066"},{"key":"S1047951113001376_ref16","first-page":"600","article-title":"Percutaneous coronary intervention utilizing a new endothelial progenitor cells antibody-coated stent: a prospective single-center registry in high-risk patients","volume":"71","author":"Miglionico","year":"2008","journal-title":"CatheterCardiovasc Interv"},{"key":"S1047951113001376_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(10)70257-8"},{"key":"S1047951113001376_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2007.06.003"},{"key":"S1047951113001376_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20690"},{"key":"S1047951113001376_ref26","first-page":"94L","article-title":"In vivo endothelial progenitor cell seeding for the accelerated endothelization of endovascular devices","volume":"92","author":"Kutryk","year":"2003","journal-title":"Am J Cardiol"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951113001376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T01:20:38Z","timestamp":1563931238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951113001376\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,18]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S1047951113001376"],"URL":"https:\/\/doi.org\/10.1017\/s1047951113001376","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,18]]}}}