{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:28:52Z","timestamp":1771356532265,"version":"3.50.1"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951114002327_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Acute rheumatic fever is an autoimmune, inflammatory, and multi-systemic disease secondary to pharyngitis and is caused by group A streptococcus. In developing countries, acute rheumatic fever is the most common cause of acquired heart disease. Gelsolin is a calcium-dependent, multi-functional actin-regulatory protein circulating in the plasma of healthy human beings. The correlation between blood gelsolin levels and inflammatory conditions suggests the potential benefit of gelsolin as a prognostic marker. The aim of the present study was to appraise the association of gelsolin and acute rheumatic carditis in childhood.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951114002327_abs2\" sec-type=\"methods\"><jats:title>Materials and Methods<\/jats:title><jats:p>Plasma gelsolin levels were measured and echocardiographic examinations were performed in patients (n=37) with acute rheumatic carditis and compared with those of age- and gender-matched healthy controls (n=24).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951114002327_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The plasma gelsolin levels in children with acute rheumatic carditis were significantly lower compared with controls (197\u00b1218 versus 322\u00b1255 mg\/L, p=0.039). There was a significant correlation among gelsolin levels and the grade of mitral regurgitation (p=0.030), left ventricular end-diastolic diameter (p=0.017), and left ventricular end-systolic diameter (p=0.028) at diagnosis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951114002327_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Levels of the gelsolin plasma isoform were decreased in patients with acute rheumatic carditis compared with healthy controls. Gelsolin may be used as a biochemical marker for acute rheumatic carditis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951114002327","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T11:27:09Z","timestamp":1416310029000},"page":"1276-1280","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Plasma gelsolin as a biomarker of acute rheumatic carditis"],"prefix":"10.1017","volume":"25","author":[{"given":"Mustafa","family":"Argun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Baykan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Narin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"\u00d6zyurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zge","family":"Pamuk\u00e7u","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferhan","family":"Elmal\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaz\u0131m","family":"\u00dcz\u00fcm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazmi","family":"Narin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"S1047951114002327_ref17","doi-asserted-by":"publisher","DOI":"10.1186\/ar2520"},{"key":"S1047951114002327_ref3","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4936"},{"key":"S1047951114002327_ref13","doi-asserted-by":"publisher","DOI":"10.3109\/03009749509095185"},{"key":"S1047951114002327_ref12","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1995.1140"},{"key":"S1047951114002327_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.02.006"},{"key":"S1047951114002327_ref15","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9806088"},{"key":"S1047951114002327_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/cc6988"},{"key":"S1047951114002327_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000201798.77133.55"},{"key":"S1047951114002327_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490150121036"},{"key":"S1047951114002327_ref2","first-page":"1","article-title":"Importance of N-terminal pro-brain natriuretic peptide in monitoring acute rheumatic carditis","volume":"28","author":"Esen","year":"2013","journal-title":"Cardiol Young"},{"key":"S1047951114002327_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9332-6"},{"key":"S1047951114002327_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/ar2547"},{"key":"S1047951114002327_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.04.002"},{"key":"S1047951114002327_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2011.10.024"},{"key":"S1047951114002327_ref18","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313507985"},{"key":"S1047951114002327_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61171-9"},{"key":"S1047951114002327_ref14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.4.1381"},{"key":"S1047951114002327_ref9","first-page":"1","article-title":"Rheumatic fever and rheumatic heart disease","volume":"923","year":"2004","journal-title":"World Health Organ Tech Rep Ser"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951114002327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T19:29:02Z","timestamp":1555788542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951114002327\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,18]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1047951114002327"],"URL":"https:\/\/doi.org\/10.1017\/s1047951114002327","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,18]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2014\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}