{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:18:54Z","timestamp":1785356334101,"version":"3.55.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951115000293_abs1\" sec-type=\"objectives\"><jats:title>Objectives<\/jats:title><jats:p>To develop a prediction model based on echocardiographic findings to estimate the probability of the need for neonatal cardiac invasive therapy, including cardiac surgery or catheter-based therapy, in foetuses with CHD.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000293_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study: a prediction model was developed based on echocardiographic findings on the examination of the<jats:italic>four-chamber<\/jats:italic>, the<jats:italic>three-<\/jats:italic>vessel, and the<jats:italic>three-vessel and tracheal views.<\/jats:italic>We assessed performance using the area under the curve of the receiver operating characteristic.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000293_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Among 291 patients with prenatal diagnosis of CHD and complete follow-up, 175 (60.1%) required neonatal cardiac invasive therapy. The variables \u201cfunctionally single ventricle\u201d, \u201cgreat artery reverse flow\u201d, and \u201ccongenital heart block\u201d had a discrimination value of 100% and were excluded from the model. In univariate and multivariate analysis, \u201cnon-visualisation of a great vessel\u201d, \u201casymmetry of the great vessels\u201d, \u201cvisualisation of one atrioventricular valve\u201d, and \u201cventricular asymmetry\u201d were significantly associated with the need for neonatal cardiac invasive therapy. The area under the receiver operating characteristic curve was 0.9324 (95% CI 0.92\u20130.97).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000293_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>A prediction model based on echocardiographic findings in foetuses with CHD, even without a definite diagnosis, allows an accurate estimation of the probability of requiring neonatal cardiac invasive therapy. This can modify patient care, especially in regions where a Foetal Medicine Specialist or a Paediatric Cardiologist is not available and referral may be extremely difficult due to social and economic barriers.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951115000293","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T10:56:33Z","timestamp":1436525793000},"page":"347-353","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal diagnosis of CHDs: a simple ultrasound prediction model to estimate the probability of the need for neonatal cardiac invasive therapy"],"prefix":"10.1017","volume":"26","author":[{"given":"Pablo","family":"Marantz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Grinenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Pestchanker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar H.","family":"Meller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Izbizky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"S1047951115000293_ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00414.x"},{"key":"S1047951115000293_ref20","first-page":"445","article-title":"Evaluation of the impact of early diagnosis of congenital heart disease","volume":"102","author":"Guerchicoff","year":"2004","journal-title":"Arch Argent Pediatr"},{"key":"S1047951115000293_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(10)70330-5"},{"key":"S1047951115000293_ref19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.9.1209"},{"key":"S1047951115000293_ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.588194"},{"key":"S1047951115000293_ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00398.x"},{"key":"S1047951115000293_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11228"},{"key":"S1047951115000293_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128690.35860.C5"},{"key":"S1047951115000293_ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.787598"},{"key":"S1047951115000293_ref12","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/pd.2844","article-title":"Tetralogy of Fallot: prediction of outcome in the mid-second trimester of pregnancy","volume":"31","author":"Escribano","year":"2011","journal-title":"Prenat Diagn"},{"key":"S1047951115000293_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131306"},{"key":"S1047951115000293_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2114"},{"key":"S1047951115000293_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11161"},{"key":"S1047951115000293_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12403"},{"key":"S1047951115000293_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11196"},{"key":"S1047951115000293_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00446-7"},{"key":"S1047951115000293_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2012.01.011"},{"key":"S1047951115000293_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.63"},{"key":"S1047951115000293_ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000144141.18560.CF"},{"key":"S1047951115000293_ref6","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.143.1.7063747"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951115000293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T22:48:41Z","timestamp":1717973321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951115000293\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,27]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1047951115000293"],"URL":"https:\/\/doi.org\/10.1017\/s1047951115000293","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,27]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}