{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T10:07:08Z","timestamp":1744193228054},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951115000372_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Our aim was to determine the optimal cut-off values, sensitivity, specificity, and diagnostic power of 12 echocardiographic parameters on the second day of life to predict subsequent ductal patency.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000372_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We evaluated preterm infants, born at \u2a7d32 weeks of gestation, starting on their second day of life, and they were evaluated every other day until ductal closure or until there were clinical signs of re-opening. We measured transductal diameter; pulmonary arterial diastolic flow; retrograde aortic diastolic flow; pulsatility index of the left pulmonary artery and descending aorta; left atrium and ventricle\/aortic root ratio; left ventricular output; left ventricular flow velocity time integral; mitral early\/late diastolic flow; and superior caval vein diameter and flow as well as performed receiver operating curve analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000372_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Transductal diameter (&gt;1.5 mm); pulmonary arterial diastolic flow (&gt;25.6 cm\/second); presence of retrograde aortic diastolic flow; ductal diameter by body weight (&gt;1.07 mm\/kg); left pulmonary arterial pulsatility index (\u2a7d0.71); and left ventricle to aortic root ratio (&gt;2.2) displayed high sensitivity and specificity (p&lt;0.0001; area under the curve&gt;0.9). Parameters with moderate sensitivity and specificity were as follows: left atrial to aortic root ratio; left ventricular output; left ventricular flow velocity time integral; and mitral early\/late diastolic flow ratio (p&lt;0.05; area under the curve 0.7\u20130.88). Descending aortic pulsatility index and superior caval vein diameter and flow (p&gt;0.05) had low diagnostic value.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000372_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Left pulmonary arterial pulsatility index, left ventricle\/aortic root ratio, and ductal diameter by body weight are useful adjuncts offering a broader outlook for predicting ductal patency.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951115000372","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T13:42:01Z","timestamp":1427895721000},"page":"439-445","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Early signs that predict later haemodynamically significant patent ductus arteriosus"],"prefix":"10.1017","volume":"26","author":[{"given":"Defne","family":"Eng\u00fcr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Deveci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcnevver 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