{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:50:54Z","timestamp":1782175854293,"version":"3.54.5"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951115000438_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the potential role of N-terminal pro-brain natriuretic peptide in the assessment of shunt severity and invasive haemodynamic parameters in children with atrial septal defects and ventricular septal defects.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000438_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This is a prospective, controlled (n:62), observational study. Correlation analysis was performed between N-terminal pro-brain natriuretic peptide levels and various invasive haemodynamic measurements in 127 children (ventricular septal defect: 64; atrial septal defect: 63). A ratio of pulmonary to systemic blood flow (Qp\/Qs\u2a7e1.5) was considered to indicate a significant shunt.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000438_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Statistically significant relationship was found between the mean N-terminal pro-brain natriuretic peptide values of the patients, with Qp\/Qs\u2a7e1.5 in both defect types and control group. For ventricular septal defect, N-terminal pro-brain natriuretic peptide level\u2a7e113.5 pg\/ml was associated with high specificity and sensitivity for determining the significant shunt. In addition, the cut-off point for determining the significant shunt for atrial septal defect was 57.9 pg\/ml. Significant positive correlation was found between all invasive haemodynamic parameters and N-terminal pro-brain natriuretic peptide levels in patients with ventricular septal defects. Whereas significant positive correlation was found only between mean pulmonary artery pressure, right ventricular end-diastolic pressure, and systemic pressure to pulmonary pressure ratio and N-terminal pro-brain natriuretic peptide levels in patients with atrial septal defects.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115000438_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated that the N-terminal pro-brain natriuretic peptide measurements could be used as a supporting parameter in determining significance of the shunt.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951115000438","type":"journal-article","created":{"date-parts":[[2015,7,10]],"date-time":"2015-07-10T10:57:23Z","timestamp":1436525843000},"page":"469-476","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Does N-terminal pro-brain natriuretic peptide correlate with measured shunt fraction in children with septal 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