{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T06:10:31Z","timestamp":1718086231222},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"S2","license":[{"start":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T00:00:00Z","timestamp":1442448000000},"content-version":"unspecified","delay-in-days":47,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stem cell therapy has the optimistic goal of regenerating the myocardium as defined by re-growth of lost or destroyed myocardium. As applied to patients with heart failure, many confuse or limit the regenerative definition to just improving myocardial function and\/or decreasing myocardial scar formation, which may not be the most important clinical outcome to achieve in this promising field of molecular medicine. Many different stem cell-based therapies have been tested and have demonstrated a safe and feasible profile in adult patients with heart failure, but with varied efficacious end points reported. Although not achieved as of yet, the encompassing goal to regenerate the heart is still believed to be within reach using these cell-based therapies in adult patients with heart failure, as the first-generation therapies are now being tested in different phases of clinical trials. Similar efforts to foster the translation of stem cell therapy to children with heart failure have, however, been limited. In this review, we aim to summarise the findings from pre-clinical models and clinical experiences to date that have focussed on the evaluation of stem cell therapy in children with heart failure. Finally, we present methodological considerations pertinent to the design of a stem cell-based trial for children with heart failure, as they represent a population of patients with very different sets of issues when compared with adult patients. As has been taught by many learned clinicians, children are not small adults!<\/jats:p>","DOI":"10.1017\/s1047951115000840","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T09:13:45Z","timestamp":1442481225000},"page":"58-66","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Stem cell therapy for CHD: towards translation"],"prefix":"10.1017","volume":"25","author":[{"given":"Brody","family":"Wehman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama T.","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachana","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunjay","family":"Kaushal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,17]]},"reference":[{"key":"S1047951115000840_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243147"},{"key":"S1047951115000840_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01131-0"},{"key":"S1047951115000840_ref28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006191"},{"key":"S1047951115000840_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.02.018"},{"key":"S1047951115000840_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.029"},{"key":"S1047951115000840_ref17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.305495"},{"key":"S1047951115000840_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.08.005"},{"key":"S1047951115000840_ref38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113009"},{"key":"S1047951115000840_ref47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.222703"},{"key":"S1047951115000840_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.049"},{"key":"S1047951115000840_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.04.006"},{"key":"S1047951115000840_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.10.093"},{"key":"S1047951115000840_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.10.035"},{"key":"S1047951115000840_ref20","doi-asserted-by":"crossref","first-page":"A20536","DOI":"10.1161\/circ.130.suppl_2.20536","article-title":"Abstract 20536: allogeneic heart stem cells to achieve myocardial regeneration (ALLSTAR): the one year phase I results","volume":"130","author":"Makkar","year":"2014","journal-title":"Circulation"},{"key":"S1047951115000840_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25321"},{"key":"S1047951115000840_ref35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.632208"},{"key":"S1047951115000840_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.006591"},{"key":"S1047951115000840_ref36","doi-asserted-by":"crossref","unstructured":"Ishigami S , Ohtsuki S , Tarui S , et al. Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome (TICAP): a prospective phase 1 controlled trial. Circ Res 2014; 116: 653\u2013664.","DOI":"10.1161\/CIRCRESAHA.116.304671"},{"key":"S1047951115000840_ref40","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0752-y"},{"key":"S1047951115000840_ref22","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2014-0195"},{"key":"S1047951115000840_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60195-0"},{"key":"S1047951115000840_ref3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00221.2012"},{"key":"S1047951115000840_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-013-0369-z"},{"key":"S1047951115000840_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.055"},{"key":"S1047951115000840_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.020"},{"key":"S1047951115000840_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.04.055"},{"key":"S1047951115000840_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000338"},{"key":"S1047951115000840_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.418"},{"key":"S1047951115000840_ref42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.084699"},{"key":"S1047951115000840_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.10.006"},{"key":"S1047951115000840_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060186"},{"key":"S1047951115000840_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61590-0"},{"key":"S1047951115000840_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl388"},{"key":"S1047951115000840_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.022"},{"key":"S1047951115000840_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.03.001"},{"key":"S1047951115000840_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.08.005"},{"key":"S1047951115000840_ref24","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-10-2-77"},{"key":"S1047951115000840_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282909"},{"key":"S1047951115000840_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16626-9"},{"key":"S1047951115000840_ref34","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.156612"},{"key":"S1047951115000840_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.10.012"},{"key":"S1047951115000840_ref39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ccd.22266","article-title":"Adverse event rates in congenital cardiac catheterization \u2013 a multi-center experience","volume":"75","author":"Bergersen","year":"2010","journal-title":"Catheter Cardiovasc Interv"},{"key":"S1047951115000840_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303180"},{"key":"S1047951115000840_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20463"},{"key":"S1047951115000840_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.28726"},{"key":"S1047951115000840_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001035"},{"key":"S1047951115000840_ref46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.305821"},{"key":"S1047951115000840_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1670"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951115000840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T05:35:40Z","timestamp":1718084140000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951115000840\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":48,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S1047951115000840"],"URL":"https:\/\/doi.org\/10.1017\/s1047951115000840","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}