{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:39:37Z","timestamp":1787495977234,"version":"build-2736575974"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The effect of Hybrid stage 1 palliation for hypoplastic left heart syndrome on right ventricular function is unknown. We sought to compare right ventricular function in normal neonates and those with hypoplastic left heart syndrome before Hybrid palliation and to assess the effect of Hybrid palliation on right ventricular function, using the right ventricular myocardial performance index and the ratio of systolic and diastolic durations.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We carried out a retrospective review of echocardiographic data on 23 infants with hypoplastic left heart syndrome who underwent Hybrid palliation and 35 normal controls. Data were acquired before Hybrid and after Hybrid palliation \u2013 post 1, 0\u20134 days; post 2, 1 week; post 3, 2\u20133 weeks; post 4, 1\u20131.5 months following Hybrid palliation.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Myocardial performance index and ratio of systolic and diastolic durations were higher in the pre-Hybrid hypoplastic left heart syndrome group (n=23) \u2013 0.47\u00b10.16 versus 0.25\u00b10.07, p<0.001; 1.59\u00b10.44 versus 1.09\u00b10.14, p<0.0001 \u2013 compared with controls (n=35). There was no significant change in the myocardial performance index at any of the post-Hybrid time points. Ratio of systolic and diastolic durations increased significantly 2 weeks after Hybrid \u2013 post 3: 2.08\u00b10.62 and post 4: 2.21\u00b10.45 versus pre: 1.59\u00b10.44, p=0.043 and 0.003. There were no significant differences in parameters between sub-groups of infants who died (n=10) and survivors (n=13).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Right ventricular myocardial performance index and ratio of systolic and diastolic durations were significantly higher in infants with hypoplastic left heart syndrome before intervention compared with controls. The ratio of systolic and diastolic durations increased significantly 2 weeks after Hybrid palliation. Our data suggest that infants with hypoplastic left heart syndrome have right ventricular dysfunction before intervention, which worsens over 2 weeks after Hybrid palliation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1017\/s1047951115001419","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T01:03:06Z","timestamp":1441674186000},"page":"867-875","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Hybrid stage 1 procedure on ventricular function in infants with hypoplastic left heart syndrome"],"prefix":"10.1017","volume":"26","author":[{"given":"Daisuke","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girija","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph E.","family":"Delius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Henry L.","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,8]]},"reference":[{"key":"S1047951115001419_ref14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/S0022-5223(94)70352-3","article-title":"Improving results with first-stage palliation for hypoplastic left heart syndrome","volume":"107","author":"Iannettoni","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S1047951115001419_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.010769"},{"key":"S1047951115001419_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-008-0021-y"},{"key":"S1047951115001419_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01168-1"},{"key":"S1047951115001419_ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.262"},{"key":"S1047951115001419_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.11.014"},{"key":"S1047951115001419_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.127"},{"key":"S1047951115001419_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.009"},{"key":"S1047951115001419_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01131-0"},{"key":"S1047951115001419_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-004-0962-4"},{"key":"S1047951115001419_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(98)70004-5"},{"key":"S1047951115001419_ref6","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function \u2013 a study in normals and dilated cardiomyopathy","volume":"26","author":"Tei","year":"1995","journal-title":"J Cardiol"},{"key":"S1047951115001419_ref9","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104709"},{"key":"S1047951115001419_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)30727-1"},{"key":"S1047951115001419_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.08.005"},{"key":"S1047951115001419_ref5","first-page":"135","article-title":"New non-invasive index for combined systolic and diastolic ventricular function","volume":"26","author":"Tei","year":"1995","journal-title":"J Cardiol"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951115001419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T22:57:27Z","timestamp":1599519447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951115001419\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,8]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S1047951115001419"],"URL":"https:\/\/doi.org\/10.1017\/s1047951115001419","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,8]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}