{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:06:49Z","timestamp":1715562409219},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951115001948_abs1\" sec-type=\"intro\"><jats:title>Introduction<\/jats:title><jats:p>Hypoxaemic congenital heart disease (CHD) patients are at higher risk of complications. The aim of this study was to compare and follow-up blood and 24-hour urine analytical data in hypoxaemic and non-hypoxaemic CHD patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115001948_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The inclusion criteria for this study were as follows: patients older than 14 years of age with a structural CHD with or without associated hypoxaemia.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115001948_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In total, 27 hypoxaemic and 48 non-hypoxaemic CHD patients were included in order to compare blood and 24-hour urine analytical data. Among hypoxaemic patients, 13 (48.1%) were male, two (7.4%) had diabetes mellitus, one of whom was a smoker, one (3.7%) had systemic arterial hypertension, and 11 (40.7%) showed pulmonary arterial hypertension. The mean follow-up time was 3.1\u00b11.9 years. Hypoxaemic CHD patients showed higher proteinuria concentrations (g\/24 hours) (0.09 (0.07; 0.46) versus 0.08 (0.07; 0.1), p=0.054) and 24-hour albumin excretion rate (\u00b5g\/min) (16.5 (11.2; 143.5) versus 4.4 (0.0; 7.6), p&lt;0.001) compared with non-hypoxaemic CHD patients; however, no significant differences were found in the proteinuria levels and in the 24-hour albumin excretion rate in CHD patients with associated hypoxaemia, both at baseline and at follow-up. When divided into groups, hypoxaemic patients with palliative shunts showed significantly higher proteinuria concentrations compared with hypoxaemic patients not operated on or with Fontan procedures (p=0.01). No significant differences were seen in 24-hour proteinuria and 24-hour albumin excretion rate during the follow-up of patients with palliative shunts.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115001948_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Hypoxaemic CHD patients have significant higher 24-hour proteinuria concentration and 24-hour albumin excretion rate compared with non-hypoxaemic CHD patients. Among hypoxaemic CHD patients, those with palliative shunts showed the highest 24-hour proteinuria concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951115001948","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T02:44:26Z","timestamp":1442544266000},"page":"1137-1143","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Medium-term follow-up of renal function in hypoxaemic congenital heart disease 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