{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:06:21Z","timestamp":1770512781220,"version":"3.49.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951115002322_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Marfan syndrome patients present important cardiac structural changes, ventricular dysfunction, and electrocardiographic changes. An abnormal heart rate response during or after exercise is an independent predictor of mortality and autonomic dysfunction. The aim of the present study was to compare heart rate recovery and chronotropic response obtained by cardiac reserve in patients with Marfan syndrome subjected to submaximal exercise.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115002322_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A total of 12 patients on \u03b2-blocker therapy and 13 off \u03b2-blocker therapy were compared with 12 healthy controls. They were subjected to submaximal exercise with lactate measurements. The heart rate recovery was obtained in the first minute of recovery and corrected for cardiac reserve and peak lactate concentration.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115002322_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Peak heart rate (141\u00b116 versus 155\u00b117 versus 174\u00b18 bpm; p=0.001), heart rate reserve (58.7\u00b19.4 versus 67.6\u00b114.3 versus 82.6\u00b14.8 bpm; p=0.001), heart rate recovery (22\u00b16 versus 22\u00b18 versus 34\u00b19 bpm; p=0.001), and heart rate recovery\/lactate (3\u00b11 versus 3\u00b11 versus 5\u00b11 bpm\/mmol\/L; p=0.003) were different between Marfan groups and controls, respectively. All the patients with Marfan syndrome had heart rate recovery values below the mean observed in the control group. The absolute values of heart rate recovery were strongly correlated with the heart rate reserve (r=0.76; p=0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115002322_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Marfan syndrome patients have reduced heart rate recovery and chronotropic deficit after submaximal exercise, and the chronotropic deficit is a strong determinant of heart rate recovery. These changes are suggestive of autonomic dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951115002322","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T04:26:39Z","timestamp":1446438399000},"page":"1274-1281","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal heart rate recovery and deficient chronotropic response after submaximal exercise in young Marfan syndrome patients"],"prefix":"10.1017","volume":"26","author":[{"given":"Paulo","family":"Peres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-6738","authenticated-orcid":false,"given":"Ant\u00f4nio C.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Beatriz 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