{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:06:20Z","timestamp":1782403580657,"version":"3.54.5"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951115002498_abs1\" sec-type=\"intro\"><jats:title>Introduction<\/jats:title><jats:p>Patients undergoing the Norwood operation consume considerable healthcare resources; however, detailed information regarding factors impacting hospitalisation costs is lacking. We evaluated the association of postoperative complications with hospital costs.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115002498_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>In the present study, we utilised a unique data set consisting of prospectively collected clinical data from the Pediatric Heart Network Single Ventricle Reconstruction trial linked at the patient level with cost data for 10 hospitals participating in the Children\u2019s Hospital Association Case Mix database during the trial period. The relationship between complications and cost was modelled using linear regression, accounting for the skewed distribution of cost, adjusting for within-centre clustering and baseline patient characteristics.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115002498_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 334 eligible Norwood records (97.5%) were matched between data sets. Overall, 82% suffered from at least one complication (median 2; with a range from 0 to 33). Those with complications had longer postoperative length of stay (25 versus 12 days, p&lt;0.001), more total ventilator days (7 versus 5 days, p&lt;0.001), and higher in-hospital mortality (17.6 versus 3.4%, p&lt;0.006). Mean adjusted hospital cost in those with a complication was $190,689 (95% CI $111,344\u2013$326,577) versus $120,584 (95% CI $69,246\u2013$209,983) in those without complications (p=0.002). Costs increased with the number of complications (1\u20132 complications=$132,800 versus 3\u20134 complications=$182,353 versus \u2a7e5 complications=$309,372 [p&lt;0.001]).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951115002498_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>This merged data set of clinical trial and cost data demonstrated that postoperative complications are common following the Norwood operation and are associated with worse clinical outcomes and higher costs. Efforts to reduce complications in this population may lead to improved outcomes and cost savings.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951115002498","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T04:34:59Z","timestamp":1451450099000},"page":"1303-1309","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Impact of postoperative complications on hospital costs following the Norwood operation"],"prefix":"10.1017","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-5411","authenticated-orcid":false,"given":"Kimberly E.","family":"McHugh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Pasquali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Scheurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"S1047951115002498_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951114002224"},{"key":"S1047951115002498_ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1310102"},{"key":"S1047951115002498_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.01.013"},{"key":"S1047951115002498_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.06.032"},{"key":"S1047951115002498_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/2150135111414065"},{"key":"S1047951115002498_ref11","first-page":"306","article-title":"Center variation in hospital costs for patients undergoing congenital heart surgery","volume":"4","author":"Pasquali","year":"2011","journal-title":"Circulation"},{"key":"S1047951115002498_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25475"},{"key":"S1047951115002498_ref4","first-page":"25","article-title":"Hospital stays, hospital charges, and in-hospital deaths among infants with selected birth defects \u2013 United States, 2003","volume":"56","year":"2007","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"S1047951115002498_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/2150135114534274"},{"key":"S1047951115002498_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3241"},{"key":"S1047951115002498_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2007.00119.x"},{"key":"S1047951115002498_ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1011024"},{"key":"S1047951115002498_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2009.00367.x"},{"key":"S1047951115002498_ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3742"},{"key":"S1047951115002498_ref2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.6.5.687"},{"key":"S1047951115002498_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.05.276"},{"key":"S1047951115002498_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.021"},{"key":"S1047951115002498_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308789"},{"key":"S1047951115002498_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25569"},{"key":"S1047951115002498_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.08.074"},{"key":"S1047951115002498_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.052"},{"key":"S1047951115002498_ref18","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2870"},{"key":"S1047951115002498_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.08.010"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951115002498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T19:03:03Z","timestamp":1555614183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951115002498\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1047951115002498"],"URL":"https:\/\/doi.org\/10.1017\/s1047951115002498","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,30]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}