{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:37:14Z","timestamp":1790350634979,"version":"4.1.0"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951116001104_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Shone\u2019s syndrome is a complex consisting of mitral valve stenosis in addition to left ventricle outflow obstruction. There are a few studies evaluating the long-term outcomes in this population. We sought to determine the long-term outcomes in our paediatric population with Shone\u2019s syndrome and the factors associated with left heart growth.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951116001104_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>All patients diagnosed with Shone\u2019s syndrome with biventricular circulation treated between 1978 and 2010 were reviewed. Baseline echocardiograms and data from catheterisations were also reviewed. Number of interventions (surgical+transcatheter), incidence of mitral valve replacement, and incidence of heart transplantation were tracked. Survival of the population and left heart structural growth were also reviewed.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951116001104_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 121 patients with Shone\u2019s syndrome presented at a median age of 28 days (0\u201317.3 years) and were followed-up for 7.2 years (0.01\u201335.5 years). These patients underwent 258 interventions during the study period, and the presence of coarctation was associated with repeat left heart interventions. The 10-year, transplant-free survival was 86%. Presence of pulmonary hypertension was associated with mortality. Left heart structural growth was seen for mitral and aortic valve annuli and left ventricular end-diastolic dimension over time.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951116001104_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Shone\u2019s syndrome patients undergo a number of left heart interventions. Coarctation of the aorta is associated with an increased likelihood for repeat interventions. Survival appears to be more favourable than expected. Significant left heart growth will occur in the population. Pulmonary hypertension is associated with an increased risk of mortality.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951116001104","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T10:14:11Z","timestamp":1469528051000},"page":"697-705","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":35,"title":["Late outcomes in children with Shone\u2019s complex: a single-centre, 20-year experience"],"prefix":"10.1017","volume":"27","author":[{"given":"George T.","family":"Nicholson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kelleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caridad M.","family":"De la Uz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo H.","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Ayres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"S1047951116001104_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.05.003"},{"key":"S1047951116001104_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.082"},{"key":"S1047951116001104_ref12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/BF00794189","article-title":"Left ventricular growth in a patient with critical coarctation of the aorta and hypoplastic left ventricle","volume":"16","author":"Page","year":"1995","journal-title":"Pediatr Cardiol"},{"key":"S1047951116001104_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.06.020"},{"key":"S1047951116001104_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(90)90861-Y"},{"key":"S1047951116001104_ref14","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01144.2004"},{"key":"S1047951116001104_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(97)00632-2"},{"key":"S1047951116001104_ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.6.2325"},{"key":"S1047951116001104_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70152-2"},{"key":"S1047951116001104_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.09.013"},{"key":"S1047951116001104_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00803-0"},{"key":"S1047951116001104_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23362"},{"key":"S1047951116001104_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(63)90098-5"},{"key":"S1047951116001104_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23500"},{"key":"S1047951116001104_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.093904"},{"key":"S1047951116001104_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.10.030"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951116001104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T20:43:07Z","timestamp":1656880987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951116001104\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S1047951116001104"],"URL":"https:\/\/doi.org\/10.1017\/s1047951116001104","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}