{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:47:27Z","timestamp":1786999647170,"version":"build-2736575974"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We hypothesised that infants with ventricular dysfunction after cardiac surgery have impaired haemodynamic response to arginine\u2013vasopressin therapy. We retrospectively reviewed the medical records of neonates and infants treated with arginine\u2013vasopressin within 48 hours of corrective or palliative cardiac surgery who underwent echocardiographic assessment of ventricular function before initiation of therapy. Patients were classified as \u201cresponders\u201d if their systolic blood pressure increased by \u2a7e10% without increase in catecholamine score or if it was maintained with decreased catecholamine score. Response was assessed 1 hour after maximum upward titration of arginine\u2013vasopressin. A total of 36 children (15 neonates) were reviewed (17 male). The median (interquartile) age was 10.4 weeks (1.1\u201326.9), and the median weight was 4.3 kg (3.2\u20135.8). Diagnoses included single ventricle (eight), arch abnormalities (five), atrioventricular septal defect (four), double-outlet right ventricle (three), tetralogy of Fallot (three), and others (13). In all, 12 patients (33%) had ventricular dysfunction. Only 15 (42%) responded favourably according to our definition 1 hour after the \u201ctarget\u201d arginine\u2013vasopressin dose was achieved. Ventricular dysfunction was not associated with poor response. The overall mortality was 25%, but mortality in patients with ventricular dysfunction was 42%. Favourable response was associated with shorter ICU stay (9.5 days versus 19.5 days, p=0.01). We conclude that arginine\u2013vasopressin fails to increase blood pressure in ~50% of hypotensive children after cardiac surgery. The response rate does not increase with duration of therapy. Ventricular function does not predict haemodynamic response. The mortality in this group is very high. Prospective comparison of vasopressin with other vasoactive agents and\/or inotropes is warranted.<\/jats:p>","DOI":"10.1017\/s104795111600189x","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T04:51:36Z","timestamp":1481691096000},"page":"1031-1040","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Arginine\u2013vasopressin therapy in hypotensive neonates and infants after cardiac surgery: response is unrelated to baseline ventricular function"],"prefix":"10.1017","volume":"27","author":[{"given":"Ilias","family":"Iliopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N.","family":"Pratap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Cassedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"S104795111600189X_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0400-0"},{"key":"S104795111600189X_ref13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.3.989"},{"key":"S104795111600189X_ref27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00508.2012"},{"key":"S104795111600189X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.05.035"},{"key":"S104795111600189X_ref23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610769200"},{"key":"S104795111600189X_ref32","first-page":"F274","article-title":"Renal microvascular effects of vasopressin and vasopressin antagonists","volume":"256","author":"Edwards","year":"1989","journal-title":"Am J Physiol"},{"key":"S104795111600189X_ref33","first-page":"F772","article-title":"Inhibition of vasopressin action by vanadate in the cortical collecting tubule","volume":"245","author":"Edwards","year":"1983","journal-title":"Am J Physiol"},{"key":"S104795111600189X_ref20","first-page":"H734","article-title":"Direct cardiac effects of vasopressin and their reversal by a vascular antagonist","volume":"251","author":"Boyle","year":"1986","journal-title":"Am J Physiol"},{"key":"S104795111600189X_ref31","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182a4284e"},{"key":"S104795111600189X_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31822f1753"},{"key":"S104795111600189X_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/cc7954"},{"key":"S104795111600189X_ref11","first-page":"H261","article-title":"Direct cardiac effects of vasopressin: role of V1- and V2-vasopressinergic receptors","volume":"255","author":"Walker","year":"1988","journal-title":"Am J Physiol"},{"key":"S104795111600189X_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181b806fc"},{"key":"S104795111600189X_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31823886bb"},{"key":"S104795111600189X_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701397"},{"key":"S104795111600189X_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.1.215"},{"key":"S104795111600189X_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00783-3"},{"key":"S104795111600189X_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.03.005"},{"key":"S104795111600189X_ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00316.2006"},{"key":"S104795111600189X_ref34","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200203000-00011"},{"key":"S104795111600189X_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181eed91d"},{"key":"S104795111600189X_ref28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.186619"},{"key":"S104795111600189X_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1265-y"},{"key":"S104795111600189X_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/cc7930"},{"key":"S104795111600189X_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.1.239"},{"key":"S104795111600189X_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112000996"},{"key":"S104795111600189X_ref30","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2256"},{"key":"S104795111600189X_ref18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0022-5223(19)34788-9","article-title":"Altered effects of vasopressin on the coronary circulation after ischemia","volume":"104","author":"Sellke","year":"1992","journal-title":"J Thorac Cardiovasc Surg"},{"key":"S104795111600189X_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2867-y"},{"key":"S104795111600189X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.10.023"},{"key":"S104795111600189X_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.suppl_2.II-182"},{"key":"S104795111600189X_ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951111000370"},{"key":"S104795111600189X_ref21","doi-asserted-by":"publisher","DOI":"10.1186\/cc5089"},{"key":"S104795111600189X_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951108001881"},{"key":"S104795111600189X_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198004000-00017"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795111600189X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T19:04:12Z","timestamp":1601233452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795111600189X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S104795111600189X"],"URL":"https:\/\/doi.org\/10.1017\/s104795111600189x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,14]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}