{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:22:06Z","timestamp":1787498526191,"version":"build-2736575974"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951116002833_abs1\" sec-type=\"general\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dilated cardiomyopathy in children causes heart failure and has a poor prognosis. Health-related quality of life in this patient group is unknown. Moreover, results may provide detailed information of parents\u2019 sense of their child\u2019s functioning. We hypothesised that health-related quality of life, as rated by parents, and the paediatric heart failure score, as assessed by physicians, have both predictive value on outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951116002833_abs2\" sec-type=\"general\">\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this prospective study, health-related quality of life was assessed by parent reports: the Infant Toddler Quality of Life questionnaire (0\u20134 years) or Child Health Questionnaire-Parent Form 50 (4\u201318 years) at 3\u20136-month intervals. We included 90 children (median age 3.8 years, interquartile range (IQR) 0.9\u201312.3) whose parents completed 515 questionnaires. At the same visit, physicians completed the New York University Pediatric Heart Failure Index. Compared with Dutch normative data, quality of life was severely impaired at diagnosis (0\u20134 years: 7\/10 subscales and 4\u201318 years: 8\/11 subscales) and \u2a7e1 year after diagnosis (3\/10 and 6\/11 subscales). Older children were more impaired (p&lt;0.05). After a median follow-up of 3 years (IQR 2\u20134), 15 patients underwent transplantation. Using multivariable time-dependent Cox regression, \u201cphysical functioning\u201d subscale and the Heart Failure Index were independently predictive of the risk of death and heart transplantation (hazard ratio 1.24 per 10% decrease of predicted, 95% confidence interval (CI) 1.06\u20131.47 and hazard ratio 1.38 per unit, 95% CI 1.19\u20131.61, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951116002833_abs3\" sec-type=\"conclusion\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Physical impairment rated by parents and heart failure severity assessed by physicians independently predicted the risk of death or heart transplantation in children with dilated cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951116002833","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T07:58:00Z","timestamp":1489478280000},"page":"1194-1202","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Parent reports of health-related quality of life and heart failure severity score independently predict outcome in children with dilated cardiomyopathy"],"prefix":"10.1017","volume":"27","author":[{"given":"Susanna L.","family":"den Boer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Baart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke H.","family":"van der Meulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabri\u00eblle G.","family":"van Iperen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad P.","family":"Backx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend D.","family":"ten Harkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas A.","family":"Rammeloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon J.","family":"du Marchie Sarvaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Tanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A.","family":"Helbing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth M.","family":"Utens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Dalinghaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"S1047951116002833_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2004.07.011"},{"key":"S1047951116002833_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-003-0348-z"},{"key":"S1047951116002833_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2010.05.002"},{"key":"S1047951116002833_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115000426"},{"key":"S1047951116002833_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs148"},{"key":"S1047951116002833_ref9","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114020"},{"key":"S1047951116002833_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0477-3"},{"key":"S1047951116002833_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.01.006"},{"key":"S1047951116002833_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5245(02)88322-5"},{"key":"S1047951116002833_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-006-9134-8"},{"key":"S1047951116002833_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90093-4"},{"key":"S1047951116002833_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00411-5"},{"key":"S1047951116002833_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.15.1867"},{"key":"S1047951116002833_ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002767"},{"key":"S1047951116002833_ref4","unstructured":"Dolgin M. (ed.). Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. Little & Brown, Boston, MA, 1994."},{"key":"S1047951116002833_ref21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.180449"},{"key":"S1047951116002833_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21612"},{"key":"S1047951116002833_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00309-7"},{"key":"S1047951116002833_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.09.006"},{"key":"S1047951116002833_ref11","unstructured":"Statistics, Netherlands [Centraal Bureau voor Statistiek]. Dutch Standard Classification of Occupations [Standaard Beroepenclassificatie]. Den Haag\/Heerlen, The Netherlands, 2010."},{"key":"S1047951116002833_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr072"},{"key":"S1047951116002833_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.01.980"},{"key":"S1047951116002833_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-14"},{"key":"S1047951116002833_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.3.235"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951116002833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T15:42:04Z","timestamp":1555515724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951116002833\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S1047951116002833"],"URL":"https:\/\/doi.org\/10.1017\/s1047951116002833","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}