{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:52:49Z","timestamp":1761238369564,"version":"3.37.3"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,9]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>A few studies have evaluated the impact of clinical trial results on practice in paediatric cardiology. The Infant Single Ventricle (ISV) Trial results published in 2010 did not support routine use of the angiotensin-converting enzyme inhibitor enalapril in infants with single-ventricle physiology. We sought to assess the influence of these findings on clinical practice.<\/jats:p><\/jats:sec>Methods<\/jats:title>A web-based survey was distributed via e-mail to over 2000 paediatric cardiologists, intensivists, cardiothoracic surgeons, and cardiac advance practice nurses during three distribution periods. The results were analysed using McNemar\u2019s test for paired data and Fisher\u2019s exact test.<\/jats:p><\/jats:sec>Results<\/jats:title>The response rate was 31.5% (69% cardiologists and 65% with >10 years of experience). Among respondents familiar with trial results, 74% reported current practice consistent with trial findings versus 48% before trial publication (p<0.001); 19% used angiotensin-converting enzyme inhibitor in this population \u201calmost always\u201d versus 36% in the past (p<0.001), and 72% reported a change in management or improved confidence in treatment decisions involving this therapy based on the trial results. Respondents familiar with trial results (78%) were marginally more likely to practise consistent with the trial results than those unfamiliar (74 versus 67%, p=0.16). Among all respondents, 28% reported less frequent use of angiotensin-converting enzyme inhibitor over the last 3 years.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Within 5 years of publication, the majority of respondents was familiar with the Infant Single Ventricle Trial results and reported less frequent use of angiotensin-converting enzyme inhibitor in single-ventricle infants; however, 28% reported not adjusting their clinical decisions based on the trial\u2019s findings.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s104795111600295x","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T04:01:11Z","timestamp":1486699271000},"page":"1265-1270","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial"],"prefix":"10.1017","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-3194","authenticated-orcid":false,"given":"Victor","family":"Zak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne T.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria L.","family":"Pemberton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jami C.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Atz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Cnota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitra","family":"Ravishankar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piers","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian W.","family":"McCrindle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele A.","family":"Frommelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Altmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard V.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Pediatric Heart Network Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"S104795111600295X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.03.018"},{"key":"S104795111600295X_ref6","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2008.064"},{"key":"S104795111600295X_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.08.030"},{"key":"S104795111600295X_ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.927988"},{"key":"S104795111600295X_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829e8807"},{"key":"S104795111600295X_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490020088036"},{"key":"S104795111600295X_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.989897"},{"key":"S104795111600295X_ref14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.096941"},{"key":"S104795111600295X_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.15.1458"},{"key":"S104795111600295X_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.986315"},{"key":"S104795111600295X_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1985.00360020156024"},{"key":"S104795111600295X_ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-8-38"},{"key":"S104795111600295X_ref4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJM200001203420301","article-title":"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators","volume":"342","author":"Yusuf","year":"2000","journal-title":"N Engl J Med"},{"key":"S104795111600295X_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.146977"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S104795111600295X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T21:43:16Z","timestamp":1555450996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S104795111600295X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S104795111600295X"],"URL":"https:\/\/doi.org\/10.1017\/s104795111600295x","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"type":"print","value":"1047-9511"},{"type":"electronic","value":"1467-1107"}],"subject":[],"published":{"date-parts":[[2017,2,10]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}