{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T02:33:16Z","timestamp":1771381996260,"version":"3.50.1"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951117001081_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>In very low birth weight infants, persistence of a patent ductus arteriosus results in morbidity and mortality. Therapies to close the ductus are effective, but clinical outcomes may depend on the accuracy of diagnosis and the timing of administration. The objective of the present study was to characterise the association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001081_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study used electronic health record data on inborn infants of gestational age \u2a7d28 weeks and birth weight &lt;1500 g who were discharged after day of life 7 from 362 neonatal ICU from 1997 to 2013. The primary outcome was death between day of life 7 and discharge. Secondary outcomes included bronchopulmonary dysplasia, necrotising enterocolitis, and grade 3 or 4 intraventricular haemorrhage.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001081_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>This study included a total of 48,551 infants with a median gestational age of 27 weeks (interquartile range 25, 28) and birth weight 870 g (706, 1050). Early echocardiography \u2013 that is, performed during days of life 2 to 6 \u2013 was performed in 15,971\/48,551 (33%) infants, and patent ductus arteriosus was diagnosed in 31,712\/48,551 (65%). The diagnosis was more common in infants who had undergone early echocardiography (14,549\/15,971 [91%] versus 17,163\/32,580 [53%], p&lt;0.001). In multivariable analysis, early echocardiography was not associated with reduced mortality (odds ratio 0.97, 95% CI 0.89\u20131.05). Results were similar in the subset of infants who received therapy for patent ductus arteriosus (odds ratio 1.01, 95% CI 0.90\u20131.15).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001081_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Early echocardiography was associated with an increased diagnosis of patent ductus arteriosus, but not with decreased mortality.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951117001081","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T08:34:25Z","timestamp":1497861265000},"page":"1732-1739","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants"],"prefix":"10.1017","volume":"27","author":[{"given":"Jan Hau","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel G.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin H.","family":"Quek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reese H.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M.","family":"Laughon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Brian","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph P.","family":"Hornik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"S1047951117001081_ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01982.x"},{"key":"S1047951117001081_ref9","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.110528"},{"key":"S1047951117001081_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.3"},{"key":"S1047951117001081_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.01.030"},{"key":"S1047951117001081_ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000371789"},{"key":"S1047951117001081_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb01668.x"},{"key":"S1047951117001081_ref7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0022-3476(75)80979-6","article-title":"The critically ill premature infant with patent ductus arteriosus and pulmonary disease-an echocardiographic assessment","volume":"86","author":"Baylen","year":"1975","journal-title":"J Pediatr"},{"key":"S1047951117001081_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303816"},{"key":"S1047951117001081_ref4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3730"},{"key":"S1047951117001081_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17476-X"},{"key":"S1047951117001081_ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000367887"},{"key":"S1047951117001081_ref8","first-page":"1048","article-title":"Serial echocardiography in very preterm infants: a pilot randomized trial","volume":"102","author":"DeMauro","year":"2013","journal-title":"Acta Paediatr"},{"key":"S1047951117001081_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6734"},{"key":"S1047951117001081_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.01.016"},{"key":"S1047951117001081_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.04.053"},{"key":"S1047951117001081_ref13","first-page":"213","article-title":"Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness","volume":"17","author":"Kliegman","year":"1987","journal-title":"Curr Probl Pediatr"},{"key":"S1047951117001081_ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2418"},{"key":"S1047951117001081_ref14","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3506"},{"key":"S1047951117001081_ref15","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.168682"},{"key":"S1047951117001081_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70172-9"},{"key":"S1047951117001081_ref18","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2005.030"},{"key":"S1047951117001081_ref19","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.118117"},{"key":"S1047951117001081_ref22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3233\/NPM-1474013","article-title":"The prevalence of and attitudes toward neonatal functional echocardiography use and training in the United States: a survey of neonatal intensive care unit medical directors","volume":"7","author":"Schachinger","year":"2014","journal-title":"J Neonatal Perinatal Med"},{"key":"S1047951117001081_ref20","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.185967"},{"key":"S1047951117001081_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.007"},{"key":"S1047951117001081_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2008.00209.x"},{"key":"S1047951117001081_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2016.12.008"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951117001081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T10:37:50Z","timestamp":1602326270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951117001081\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,19]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1047951117001081"],"URL":"https:\/\/doi.org\/10.1017\/s1047951117001081","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,19]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}