{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:44:06Z","timestamp":1756385046010},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951117001147_abs1\" sec-type=\"objectives\"><jats:title>Objectives<\/jats:title><jats:p>Tetralogy of Fallot with absent pulmonary valve syndrome is a rare form of tetralogy of Fallot with dilatation of large pulmonary arteries. Prognosis is related to the severity of the cardiac malformation and to bronchial tree compression by dilated pulmonary arteries. This study analyses the prenatal echographic lung appearance in fetuses with tetralogy of Fallot with absent pulmonary valve and discusses its significance.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001147_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We carried out a retrospective review of fetal and postnatal files of nine fetuses diagnosed with tetralogy of Fallot with absent pulmonary valve syndrome in our institution. Correlations of prenatal ultrasound and cardiac imaging findings were obtained with outcome.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001147_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Abnormal heterogeneous fetal lung echogenicity was detected in eight cases out of nine, always associated with significant lobar arterial dilatation. This aspect was well correlated with postnatal imaging and outcome in the four neonatal cases. The only fetus with normal lung echogenicity also had lower degree of pulmonary artery dilatation in the series.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001147_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that a heterogeneous ultrasound appearance of the fetal lungs can be detected in utero in the most severe cases. This aspect suggests an already significant compression of the fetal bronchial tree by the dilated arteries that may have prognostic implications.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951117001147","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T05:28:15Z","timestamp":1499146095000},"page":"1740-1747","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Significance of lung anomalies in fetuses affected by tetralogy of Fallot with absent pulmonary valve 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