{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:00:07Z","timestamp":1789884007464,"version":"4.0.1"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951117001159_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Previous studies suggest that children with congenital cardiac diagnoses report lower quality of life when compared with healthy norms. A few studies have evaluated quality of life specifically in children born with hypoplastic left heart syndrome, a condition requiring several surgeries before age three. The aim of this study was to use an empirically validated and standardised measure \u2013 the Pediatric Quality of Life Inventory \u2013 to evaluate quality of life in children with hypoplastic left heart syndrome and compare the findings with similar, medically complicated samples.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001159_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The parent-report Pediatric Quality of Life Inventory was administered, and demographic information was collected through an internet portal. A total of 121 caregivers of children with hypoplastic left heart syndrome responded. The sample included children aged 2\u201318 years (M=10.81 years). Independent sample t-tests were used to compare our sample with published norms of healthy children and children with acute or chronic illnesses.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001159_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Children with hypoplastic left heart syndrome were rated as having significantly lower overall quality-of-life scores (M=59.69) compared with published norms of children without medical diagnoses (M=83.00) and those with acute (M=78.70) or chronic (M=77.19) illnesses (p&lt;0.001). Children with hypoplastic left heart syndrome complicated by a stroke or seizure (15%) reported the lowest quality of life. The results held for all subscales (p&lt;0.001).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001159_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Children with hypoplastic left heart syndrome appear to be a significantly vulnerable population with difficulties in functioning across psychosocial domains and across the age span. Further research is required to facilitate early identification of the need for resources for these children and families, especially for children who experience additional medical complications.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951117001159","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T06:12:54Z","timestamp":1503987174000},"page":"21-26","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Children with hypoplastic left heart syndrome have lower quality of life than healthy controls and children with other illnesses"],"prefix":"10.1017","volume":"28","author":[{"given":"Nicole","family":"Dempster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford L","family":"Cua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Wernovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Caris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent","family":"Neely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Butz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"S1047951117001159_ref2","unstructured":"Congenital Heart Public Health Consortium (CHPHC) of the American Academy of Pediatrics (AAP). Congenital Heart Disease Fact Sheet, 2016. Retrieved February 14, 2016, from https:\/\/www.aap.org\/en-us\/advocacy-and-policy\/aap-health-initiatives\/chphc\/Pages\/Fact-Sheet"},{"key":"S1047951117001159_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200108000-00006"},{"key":"S1047951117001159_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70007-9"},{"key":"S1047951117001159_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-9-6"},{"key":"S1047951117001159_ref9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/pch\/5.4.219","article-title":"Hypoplastic left heart syndrome: prognosis and management options","volume":"5","author":"Fruitman","year":"2000","journal-title":"Paediatr Child Health"},{"key":"S1047951117001159_ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106806"},{"key":"S1047951117001159_ref17","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1282"},{"key":"S1047951117001159_ref19","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318265ee8a"},{"key":"S1047951117001159_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951115000086"},{"key":"S1047951117001159_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-5-43"},{"key":"S1047951117001159_ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2973"},{"key":"S1047951117001159_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S104795111100165X"},{"key":"S1047951117001159_ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3778"},{"key":"S1047951117001159_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0679-3"},{"key":"S1047951117001159_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.11.016"},{"key":"S1047951117001159_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70139-4"},{"key":"S1047951117001159_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-006-0013-4"},{"key":"S1047951117001159_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2007.00039.x"},{"key":"S1047951117001159_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.022"},{"key":"S1047951117001159_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951105001253"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951117001159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T21:25:45Z","timestamp":1555363545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951117001159\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1047951117001159"],"URL":"https:\/\/doi.org\/10.1017\/s1047951117001159","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}