{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:17:27Z","timestamp":1790648247094,"version":"4.1.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Obesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors.<\/jats:p><\/jats:sec>Objective<\/jats:title>To determine early markers of left ventricular affection in obese patients before the appearance of left ventricular hypertrophy.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this cross-sectional study, we evaluated 42 obese patients and 30 healthy controls. Their ages ranged from 6 to 19 years. Studied children were subjected to anthropometric, lipid profile, and serum Troponin I level measurements. Echocardiographic evaluation performed to assess the left ventricle included left ventricular dimension measurement using motion-mode echocardiography, based on which patients with left ventricular hypertrophy (10 patients) were eliminated, as well as conventional and tissue Doppler imaging.<\/jats:p><\/jats:sec>Results<\/jats:title>Tissue Doppler findings in the study groups showed that the ratio of transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity (E\/e\u2032) was significantly higher in cases compared with controls [6.9\u00b11.4 versus 9.0\u00b11.6, p (Pearson\u2019s coefficient)=0.001, respectively]. The level of cardiac troponin I was significantly higher in cases compared with controls [0.14\u00b10.39 ng\/ml versus 0.01\u00b10.01 ng\/ml, p (Pearson\u2019s coefficient)=0.047, respectively] and there was a significant correlation between troponin I and transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity ratio (E\/e\u2032) [R (correlation coefficient)=0.6].<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Tissue Doppler Imaging and Troponin I evaluation proved useful tools to detect early affection of the left ventricle in obese patients even in the absence of left ventricular hypertrophy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951117001627","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T03:40:17Z","timestamp":1502077217000},"page":"76-84","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Left ventricular diastolic dysfunction without left ventricular hypertrophy in obese children and adolescents: a Tissue Doppler Imaging and Cardiac Troponin I Study"],"prefix":"10.1017","volume":"28","author":[{"given":"Sonia A.","family":"El Saiedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa F.","family":"Mira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar A.","family":"Sharaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysoun M.","family":"Al Musaddar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania M. H.","family":"El Kaffas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8876-3229","authenticated-orcid":false,"given":"Antoine F.","family":"AbdelMassih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab H. Y.","family":"Barsoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"S1047951117001627_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12798"},{"key":"S1047951117001627_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2005.10.012"},{"key":"S1047951117001627_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92234-6"},{"key":"S1047951117001627_ref9","volume-title":"Crescere nel mondo","author":"Ghalli","year":"2008"},{"key":"S1047951117001627_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl163"},{"key":"S1047951117001627_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.4.501"},{"key":"S1047951117001627_ref6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.4.1784"},{"key":"S1047951117001627_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200104000-00003"},{"key":"S1047951117001627_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.2.157"},{"key":"S1047951117001627_ref19","doi-asserted-by":"publisher","DOI":"10.1021\/bi00305a018"},{"key":"S1047951117001627_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"S1047951117001627_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.03.003"},{"key":"S1047951117001627_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nm1137"},{"key":"S1047951117001627_ref1","doi-asserted-by":"crossref","unstructured":"Roberto CA , Swinburn B , Hawkes C , Huang TTK , Costa SA , Ashe M , et al. Patchy progress on obesity prevention: emerging examples, entrenched barriers and new thinking. Lancet 2015; 385: 2400\u20132409.","DOI":"10.1016\/S0140-6736(14)61744-X"},{"key":"S1047951117001627_ref8","doi-asserted-by":"publisher","DOI":"10.7570\/kjo.2016.25.3.129"},{"key":"S1047951117001627_ref18","doi-asserted-by":"publisher","DOI":"10.3390\/nu5041218"},{"key":"S1047951117001627_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.12.005"},{"key":"S1047951117001627_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90491-4"},{"key":"S1047951117001627_ref15","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function\u2013a study in normals and dilated cardiomyopathy","volume":"26","author":"Tei","year":"1995","journal-title":"J Cardiol"},{"key":"S1047951117001627_ref11","first-page":"1091","article-title":"ACC\/AHA\/ASE 2003 guideline update for the clinical application of echocardiography","volume":"16","author":"Cheitlin","year":"2003","journal-title":"J Am Soc Echocardiogr"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951117001627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T17:26:58Z","timestamp":1555349218000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951117001627\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1047951117001627"],"URL":"https:\/\/doi.org\/10.1017\/s1047951117001627","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}