{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:33:12Z","timestamp":1789572792046,"version":"build-2803163510"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951117001640_abs1\" sec-type=\"general\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Norwood palliation for patients with single ventricle heart disease is associated with a significant risk for acute kidney injury, which portends a worse prognosis. We sought to investigate the impact of hybrid stage I palliation (Hybrid) on acute kidney injury risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951117001640_abs2\" sec-type=\"general\">\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This study is a single-centre prospective case\u2013control study of seven consecutive neonates with single ventricle undergoing Hybrid palliation. Levels of serum creatinine and four novel urinary biomarkers, namely neutrophil gelatinase-associated lipocalin, interleukin-18, liver fatty acid-binding protein, and kidney injury molecule-1, were obtained before and after palliation. Acute kidney injury was defined as a \u2a7e50% increase in serum creatinine within 48 hours after the procedure. Data were compared with a contemporary cohort of 12 neonates with single ventricle who underwent Norwood palliation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951117001640_abs3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients who underwent Hybrid were more likely to be high-risk candidates (86 versus 25%, p=0.01) compared with those who underwent Norwood. Despite similar preoperative serum creatinine levels, there was a trend towards higher levels of postoperative peak serum creatinine (0.7 [0.63, 0.94] versus 0.56 [0.47, 0.74], p=0.06) and rate of acute kidney injury (67 versus 29%, p=0.17) in the Norwood cohort. Preoperative neutrophil gelatinase-associated lipocalin (58.4 [11, 86.3] versus 6.3 [5, 16.2], p=0.07) and interleukin-18 (30.6 [9.6, 167.2] versus 6.3 [6.3, 16.4], p=0.03) levels were higher in the Hybrid cohort. Nevertheless, longitudinal mixed-effect models demonstrated Hybrid palliation to be a protective factor against increased postoperative levels of neutrophil gelatinase-associated lipocalin (estimate \u22121.8 [\u22123.0, \u22129.0], p&lt;0.001) and liver fatty acid-binding protein (\u221249.3 [\u221289.7, \u22128.8], p=0.018).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951117001640_abs4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single-centre case\u2013control study, postoperative acute kidney injury risk did not differ significantly by single ventricle stage I treatment strategy; however, postoperative elevation in novel urinary biomarkers, consistent with subclinical kidney injury, was encountered in the Norwood cohort but not in the Hybrid cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951117001640","type":"journal-article","created":{"date-parts":[[2017,9,10]],"date-time":"2017-09-10T21:41:13Z","timestamp":1505079673000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["First-stage palliation strategy for univentricular heart disease may impact risk for acute kidney injury"],"prefix":"10.1017","volume":"28","author":[{"given":"Bryan H.","family":"Goldstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-9280","authenticated-orcid":false,"given":"David M.","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley S.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L. S.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine D.","family":"Krawczeski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"S1047951117001640_ref7","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104709"},{"key":"S1047951117001640_ref26","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.422"},{"key":"S1047951117001640_ref25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215623"},{"key":"S1047951117001640_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1359-x"},{"key":"S1047951117001640_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.051"},{"key":"S1047951117001640_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-006-1444-7"},{"key":"S1047951117001640_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.009"},{"key":"S1047951117001640_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000047"},{"key":"S1047951117001640_ref11","first-page":"1","article-title":"KDIGO clinical practice guideline for acute kidney injury","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"S1047951117001640_ref24","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000088027.54400.C6"},{"key":"S1047951117001640_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181b806fc"},{"key":"S1047951117001640_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.054"},{"key":"S1047951117001640_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000734"},{"key":"S1047951117001640_ref13","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04010907"},{"key":"S1047951117001640_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.06.098"},{"key":"S1047951117001640_ref10","doi-asserted-by":"crossref","first-page":"A13540","DOI":"10.1161\/circ.132.suppl_3.13540","article-title":"Peritoneal dialysis vs. furosemide for the treatment of oliguria in infants after cardiopulmonary bypass","volume":"132","author":"Kwiatkowski","year":"2015","journal-title":"Circulation"},{"key":"S1047951117001640_ref5","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04240415"},{"key":"S1047951117001640_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.11.037"},{"key":"S1047951117001640_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.017"},{"key":"S1047951117001640_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.270"},{"key":"S1047951117001640_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.021"},{"key":"S1047951117001640_ref14","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.5.128"},{"key":"S1047951117001640_ref20","doi-asserted-by":"publisher","DOI":"10.1177\/2150135114535272"},{"key":"S1047951117001640_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.04.127"},{"key":"S1047951117001640_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74811-X"},{"key":"S1047951117001640_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.06.021"},{"key":"S1047951117001640_ref21","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000051365.81920.28"},{"key":"S1047951117001640_ref23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679654"},{"key":"S1047951117001640_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.066"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951117001640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T11:51:47Z","timestamp":1659441107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951117001640\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,11]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1047951117001640"],"URL":"https:\/\/doi.org\/10.1017\/s1047951117001640","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,11]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}