{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:06:40Z","timestamp":1790957200149,"version":"4.1.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1047951117001809_abs1\" sec-type=\"general\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the prevalence of acute kidney injury after first-stage surgical palliation in patients with a single ventricle and to explore associated risk factors and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951117001809_abs2\" sec-type=\"general\">\n                    <jats:title>Design and patients<\/jats:title>\n                    <jats:p>This single-centre retrospective study included neonates who underwent either Norwood or Hybrid procedure from 2008 to 2015 for a single ventricle. Postoperative acute kidney injury was defined using the paediatric risk, injury, failure, loss, end-stage renal disease (pRIFLE), criteria within 72 hours of the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951117001809_abs3\" sec-type=\"general\">\n                    <jats:title>Main results<\/jats:title>\n                    <jats:p>Our cohort (n=48) underwent surgical palliation at a mean (SD) age of 12 (11) days. Postoperative acute kidney injury was diagnosed in 14 (29%) patients. The prevalence of acute kidney injury in the Hybrid group was 16% and 53% in the Norwood group. Infants who developed acute kidney injury underwent surgery at younger ages [6 (5\u201310) versus 10 (8\u201316) days, p=0.016], and had a higher peak lactate level in the initial 24 hours [5.9 (4.2\u20139.1) versus 3.4 (2.4\u20136.7), p=0.007]. Norwood procedure was significantly associated with acute kidney injury [odds ratio 11.7 (95% confidence interval 1.3\u2013101.9), p=0.03]. ICU stay [38 (21\u201384) versus 16 (6\u201345) days, p=0.038] and time to extubation [204 (120\u2013606) versus 72 (26\u2013234) hours, p=0.014] were longer in those with acute kidney injury. The two patients who developed early postoperative renal failure as per pRIFLE died before discharge from associated comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1047951117001809_abs4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acute kidney injury occurs in a third of the patients with single ventricle after surgical palliation but is mostly transient. Norwood, compared with Hybrid procedure, is a risk factor for postoperative acute kidney injury, which, in turn, is associated with longer ICU stay and time to extubation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1047951117001809","type":"journal-article","created":{"date-parts":[[2017,9,10]],"date-time":"2017-09-10T21:40:45Z","timestamp":1505079645000},"page":"261-268","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["Acute kidney injury following first-stage palliation in hypoplastic left heart syndrome: hybrid versus Norwood palliation"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-8841","authenticated-orcid":false,"given":"Richard U.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girija","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Henry L.","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph E.","family":"Delius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"S1047951117001809_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.09.014"},{"key":"S1047951117001809_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.054"},{"key":"S1047951117001809_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.06.021"},{"key":"S1047951117001809_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1533-y"},{"key":"S1047951117001809_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.008"},{"key":"S1047951117001809_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197905000-00006"},{"key":"S1047951117001809_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.04.127"},{"key":"S1047951117001809_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2011.03532.x"},{"key":"S1047951117001809_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0440-2"},{"key":"S1047951117001809_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.063"},{"key":"S1047951117001809_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.10.046"},{"key":"S1047951117001809_ref20","first-page":"377","article-title":"Serum interleukin 6 levels as an early marker of acute kidney injury on children after cardiac surgery","volume":"22","author":"Miklaszewska","year":"2013","journal-title":"Adv Clin Exp Med"},{"key":"S1047951117001809_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104709"},{"key":"S1047951117001809_ref7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0031-1295569","article-title":"Does bilateral pulmonary banding in comparison to Norwood procedure improve outcome in neonates with hypoplastic left heart syndrome beyond second-stage palliation? 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