{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:39:42Z","timestamp":1757702382599},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951117001950_abs1\" sec-type=\"general\"><jats:title>Aim<\/jats:title><jats:p>We aimed to study the dimensions, systolic and diastolic functions of the left ventricle; dimensions and elasticity of the aorta; and carotid intima-media thickness and flow-mediated dilatation of the brachial artery in mitral valve prolapse.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001950_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The study group consisted of 43 patients (mean age=13.3\u00b13.9) and 42 healthy children (mean age=12.9\u00b13.4). Left ventricular end-diastolic, end-systolic, left atrial diameters, interventricular septum, and left ventricular posterior wall thickness were measured. Ejection and shortening fractions were calculated by M-mode. Measurements were adjusted to the body surface area. Mitral annulus, and systolic and diastolic diameters of the aortic annulus and aorta at each level were obtained; z-scores, aortic strain, distensibility, stiffness index were calculated. Carotid intima-media thickness and flow-mediated dilatation were studied. Patients were classified as classical\/non-classical mitral valve prolapse and younger\/older patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001950_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Left ventricular end-systolic, end-diastolic, and left atrial diameters (p=0.009, p=0.024, p=0.001) and aortic z-scores at annulus, sinus valsalva, and sinotubuler junction were larger (p=0.008, p=0.003, p=0.002, respectively) in the mitral valve prolapse group. Aortic strain and distensibility increased and stiffness decreased at the ascending aorta in the patient group (p=0.012, 0.020, p=0.019, respectively). Classical mitral valve prolapse had lower strain and distensibility and higher stiffness of the aorta at sinus valsalva level (p=0.010, 0.027, 0.004, respectively). Carotid intima-media thickness was thinner in the patient group, especially in the non-classical mitral valve prolapse group (p=0.037). Flow-mediated dilatation did not differ among the groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117001950_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>Mitral valve prolapse is a systemic disease of the connective tissue causing enlarged cardiac chambers and increased elasticity of the aorta. Decreased carotid intima-media thickness in this group may indicate low atherosclerosis risk.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951117001950","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T12:16:55Z","timestamp":1510057015000},"page":"292-301","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Aortic elasticity and carotid intima-media thickness in children with mitral valve prolapse"],"prefix":"10.1017","volume":"28","author":[{"given":"Elif","family":"Erolu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Akal\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nil\u00fcfer","family":"\u00c7etiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berna","family":"\u015eaylan \u00c7evik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"S1047951117001950_ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2006.00342.x"},{"key":"S1047951117001950_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.02.013"},{"key":"S1047951117001950_ref48","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2017_29"},{"key":"S1047951117001950_ref47","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1963"},{"key":"S1047951117001950_ref44","first-page":"755","article-title":"Modification of the sympathovagal interaction in mitral valve prolapse syndrome. 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