{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:40:43Z","timestamp":1760985643599},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"unspecified","delay-in-days":28,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Marfan syndrome, bicuspid aortic valve, and\/or coarctation of the aorta are associated with medial abnormalities of the ascending aortic or para-coarctation aorta. Medial abnormalities in the ascending aorta are prevalent in other type of patients with a variety of CHDs such as single ventricle, persistent truncus arteriosus, transposition of the great arteries, hypoplastic left heart syndrome, and tetralogy of Fallot, encompassing a wide age range and may predispose to dilatation, aneurysm, and rapture necessitating aortic valve and root surgery. These CHDs exhibit ongoing dilatation of the aortic root and reduced aortic elasticity and increased aortic stiffness that may relate to intrinsic properties of the aortic root. These aortic dilatation and increased stiffness can induce aortic aneurysm, rapture of the aorta, and aortic regurgitation, but also provoke left ventricular hypertrophy, reduced coronary artery flow, and left ventricular failure. Therefore, a new clinical entity can be used to call this association of aortic pathophysiological abnormality, aortic dilation, and aorto-left ventricular interaction \u2013 \u201caortopathy\u201d.<\/jats:p>","DOI":"10.1017\/s1047951117002116","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T15:01:45Z","timestamp":1514559705000},"page":"1959-1965","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Landmark lecture: Perloff lecture: Tribute to Professor Joseph Kayle Perloff and lessons learned from him: aortopathy in adults with CHD"],"prefix":"10.1017","volume":"27","author":[{"given":"Koichiro","family":"Niwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"S1047951117002116_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.05.024"},{"key":"S1047951117002116_ref38","first-page":"e118","article-title":"Bicuspid aortic valve leaflet morphology in relation to aortic root morphology: a study of 300 patients undergoing open-heart surgery","volume":"40","author":"Jackson","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"S1047951117002116_ref34","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.suppl_1.1799"},{"key":"S1047951117002116_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00715-0"},{"key":"S1047951117002116_ref12","doi-asserted-by":"crossref","first-page":"628","DOI":"10.5694\/j.1326-5377.1952.tb94647.x","article-title":"Bicuspid aortic valve associated with aneurysmal dilatation of the ascending aorta","volume":"2","author":"Reid","year":"1952","journal-title":"Med J Aust"},{"key":"S1047951117002116_ref36","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-6-51"},{"key":"S1047951117002116_ref27","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138392.68841.d3"},{"key":"S1047951117002116_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.12.044"},{"key":"S1047951117002116_ref41","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.091199"},{"key":"S1047951117002116_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90418-1"},{"key":"S1047951117002116_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.3.393"},{"key":"S1047951117002116_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-1618-4.00007-9"},{"key":"S1047951117002116_ref40","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32770"},{"key":"S1047951117002116_ref23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000028462.88597.AD"},{"key":"S1047951117002116_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90218-1"},{"key":"S1047951117002116_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70175-9"},{"key":"S1047951117002116_ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.4.689"},{"key":"S1047951117002116_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.130"},{"key":"S1047951117002116_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.09.141"},{"key":"S1047951117002116_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.537928"},{"key":"S1047951117002116_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01837-3"},{"key":"S1047951117002116_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91211-1"},{"key":"S1047951117002116_ref33","first-page":"336","article-title":"Histopathologic findings in human aortic media associated with pregnancy","volume":"83","author":"Monalo-Estrell","year":"1967","journal-title":"Arch Pathol"},{"key":"S1047951117002116_ref35","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.16.2138"},{"key":"S1047951117002116_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)65727-X"},{"key":"S1047951117002116_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80188-3"},{"key":"S1047951117002116_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(70)90006-8"},{"key":"S1047951117002116_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.07.002"},{"key":"S1047951117002116_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02275142"},{"key":"S1047951117002116_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.1.19"},{"key":"S1047951117002116_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.12.061"},{"key":"S1047951117002116_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.114306"},{"key":"S1047951117002116_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2011.00520.x"},{"key":"S1047951117002116_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90479-7"},{"key":"S1047951117002116_ref44","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2013.43.4.215"},{"key":"S1047951117002116_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(99)70002-4"},{"key":"S1047951117002116_ref26","first-page":"506","article-title":"Histological study of the great arteries in patients with arterial switch operation","volume":"12","author":"Takeuchi","year":"1996","journal-title":"Act Ped Cardiol Jpn"},{"key":"S1047951117002116_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-009-9435-0"},{"key":"S1047951117002116_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.02.080"},{"key":"S1047951117002116_ref43","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.2.202"},{"key":"S1047951117002116_ref37","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.132092"},{"key":"S1047951117002116_ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.57.5.1022"},{"key":"S1047951117002116_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951106000953"},{"key":"S1047951117002116_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80004-0"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951117002116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T21:13:06Z","timestamp":1570569186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951117002116\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1047951117002116"],"URL":"https:\/\/doi.org\/10.1017\/s1047951117002116","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}