{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:31:36Z","timestamp":1789943496455,"version":"4.0.1"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951117002372_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>It is suggested that folic acid and\/or multivitamins, taken periconceptionally, have a role in the prevention of many congenital anomalies. The aim of this study was to determine the serum micronutrient levels in mother\u2013infant pairs with CHD compared with those with healthy newborns and their mothers.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117002372_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Serum levels of folic acid, homocysteine, zinc, vitamin A, vitamin D, and vitamin B<jats:sub>12<\/jats:sub>were measured from 108 newborns with CHD (study group) and 103 healthy newborns (control group). The mothers\u2019 micronutrient levels were also measured simultaneously.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117002372_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>When compared with healthy newborns, for both maternal and neonatal data, homocysteine and zinc levels were higher and vitamin D levels were lower in the study group. In multivariate analysis, only maternal high zinc levels were associated with CHD in the newborns (p=0.02, OR: 0.9, 95% CI 0.8\u20130.9). The results did not change when analysed for truncal anomalies including truncus arteriosus, tetralogy of Fallot, and d-transposition of great arteries. There were positive correlations between maternal and neonatal levels of micronutrients, except vitamin B<jats:sub>12<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951117002372_abs4\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>We thought that high homocysteine and zinc levels and low vitamin D levels in mother\u2013infant pairs might have a role in the aetiopathogenesis of CHD. Large-scale, prospective studies are needed to clarify the role of micronutrients in CHDs.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951117002372","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T08:56:25Z","timestamp":1516697785000},"page":"523-529","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Maternal and neonatal micronutrient levels in newborns with CHD"],"prefix":"10.1017","volume":"28","author":[{"given":"Dilek","family":"Dilli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazan Neslihan","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utku 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