{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:43:41Z","timestamp":1740141821413,"version":"3.37.3"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"},{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951118000707_abs1\" sec-type=\"objectives\"><jats:title>Objectives<\/jats:title><jats:p>The goal of this study was to assess the utility of serial electrocardiograms in routine follow-up of paediatric Marfan patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118000707_abs2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Children \u2a7d18 years who met the revised Ghent criteria for Marfan syndrome and received a 12-lead electrocardiogram and echocardiogram within a 3-month period were included. Controls were matched by age, body surface area, gender, race, and ethnicity, and consisted of patients assessed in clinic with a normal cardiac evaluation. Demographic, clinical, echocardiographic, and electrocardiographic data were collected.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118000707_abs3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 45 Marfan patients (10.8 [2.4\u201317.1] years) and 37 controls (12.8 [1.3\u201317.1] years) were included. Left atrial enlargement and left ventricular hypertrophy were more frequently present on 12-lead electrocardiogram of Marfan patients compared with controls (12 (27%) versus 0 (0%), p&lt;0.001; and 8 (18%) versus 0 (0%), p=0.008, respectively); however, only two patients with left atrial enlargement on 12-lead electrocardiogram were confirmed to have left atrial enlargement by echocardiogram, and one patient had mild left ventricular hypertrophy by echocardiogram, not appreciated on 12-lead electrocardiogram. QTc interval was longer in Marfan patients compared with controls (427\u00b116 versus 417\u00b122 ms, p=0.03), with four Marfan patients demonstrating borderline prolonged QTc intervals for gender.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951118000707_abs4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>While Marfan patients exhibited a higher frequency of left atrial enlargement and left ventricular hypertrophy on 12-lead electrocardiograms compared with controls, these findings were not supported by echocardiography. Serial 12-lead electrocardiograms in routine follow-up of asymptomatic paediatric Marfan patients may be more appropriate for a subgroup of Marfan patients only, specifically those with prolonged QTc interval at their baseline visit.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951118000707","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T05:18:18Z","timestamp":1530681498000},"page":"1009-1013","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Utility of serial 12-lead electrocardiograms in children with Marfan syndrome"],"prefix":"10.1017","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-8664","authenticated-orcid":false,"given":"Alisa A.","family":"Arunamata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Ceresnak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Dubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger L.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif S.","family":"Selamet Tierney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"S1047951118000707_ref5","first-page":"273","article-title":"Ventricular dysrhythmias in children with Marfan\u2019s syndrome","volume":"139","author":"Chen","year":"1985","journal-title":"Am J Dis Child"},{"key":"S1047951118000707_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072785"},{"key":"S1047951118000707_ref1","first-page":"1993","volume-title":"GeneReviews","author":"Dietz","year":"2016"},{"key":"S1047951118000707_ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.115125000.x"},{"key":"S1047951118000707_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"S1047951118000707_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(80)90062-9"},{"key":"S1047951118000707_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02699-2"},{"key":"S1047951118000707_ref8","first-page":"61","volume-title":"Echocardiography in Pediatric and Congenital Heart Disease","author":"Sluysmans","year":"2009"},{"key":"S1047951118000707_ref9","first-page":"765","volume-title":"Echocardiography in Pediatric and Congenital Heart 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